Results 81 to 90 of about 272,000 (300)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Elucidating protonation pathways in CO2 photoreduction using the kinetic isotope effect

Nature Communications
The surge in anthropogenic CO2 emissions from fossil fuel dependence demands innovative solutions, such as artificial photosynthesis, to convert CO2 into value-added products.
Shikang Yin, Yiying Zhou, Zhonghuan Liu, Huijie Wang, Xiaoxue Zhao, Zhi Zhu, Yan Yan, Pengwei Huo   +7 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Transfer of technology of “Green chemistry” in education [PDF]

, 2015
Работа посвящена проблемам «зеленой химии» и внедрению технологий «зеленой химии» в образование. Ученые и преподаватели Уральского федерального университета предлагают раскрыть значимость химии для школьников и студентов бакалавриата и магистратуры ...
Селезнева, И. С., Shabunina, O. V., Иванцова, М. Н., Безматерных, М. А., Bezmaternikh, M. A., Ivantsova, M. N., Selezneva, I. S., Шабунина, О. В.   +7 more
core  

Multicomponent Synthesis: Cohesive Integration of Green Chemistry Principles

, 2022
The application of multicomponent reactions (MCRs) in the generation of compound libraries has long been recognized as a key strategy for the development of lead matter in drug discovery.
Orru, Romano V.A., Cioc, Razvan, Ruijter, Eelco, Richardson, Paul F.   +3 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Photocatalytic Synthesis in Green Chemistry: Methods and Applications [PDF]

MATEC Web of Conferences
With the advancement of urbanization and industrialization, global environmental degradation and shortage of non-renewable energy are becoming increasingly serious. Humanity’s demand for green energy is growing.
Li Jiaxiang, Li Siye
doaj   +1 more source

Study of the carbohydrate peeling and stopping reactions under the conditions of oxygen-alkali pulping. Project 3265, report two : a progress report to members of the Institute of Paper Chemistry.

, 1976
"September 3, 1976.""The Institute of Paper Chemistry, John W. Green, senior research associate, Division of Natural Materials and Systems, Norman S. Thompson, senior research associate, Division of Materials Engineering and Processes, Irwin A.
Green, John W., Thompson, Norman S., Pearl, Irwin A., Swanson, John W.   +3 more
core