Results 61 to 70 of about 1,078,562 (296)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A highly active magnetic solid superbase catalyst for hydrocracking C-O bridged bonds of extraction residue from Huolinguole lignite

Applied Catalysis O: Open
A highly active magnetic solid superbase (MSS) catalyst, Mg2Si supported on Fe3O4@SiO2, was synthesized and characterized using transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX), vibrating sample magnetometry (VSM), X-ray
Weiwei Ma, Taoyuan Hao, Xinwang Song, Xia Liu   +3 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Highly selective electrochemical hydrogenation of alkynes: Rapid construction of mechanochromic materials [PDF]

, 2019
Electrochemical hydrogenation has emerged as an environmentally benign and operationally simple alternative to traditional catalytic reduction of organic compounds.
Ge, Haibo, Li, Bijin
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An alkaline electrolyzer having a diaphragm surface coating to enable bubble formation and thus reduce the crossover rates of the product gases

Invention Disclosure
Alkaline electrolyzer technology is widely considered the most mature and cost-effective way of producing green hydrogen, provided the electricity to operate the electrolyzer is generated via renewable energies.
Torsten Berning, Diogo Loureiro Martinho
doaj   +1 more source

Synthesis and antibacterial effects of cobalt–cellulose magnetic nanocomposites [PDF]

, 2017
© The Royal Society of Chemistry. Green synthesis is employed to prepare cobalt/cellulose nanocomposites with cubic (α-cobalt) cobalt as a main component with antibacterial and magnetic properties. An in situ reduction of aqueous solutions of cobalt ions
Alahmadi, N. S., Betts, J. W., Cheng, F., Francesconi, M. G., Francesconi, M. Grazia, Kelly, S. M., Kelly, S.M., Kornherr, A., Kornherr, Andreas, Prior, T. J., Prior, Timothy, Wadhawan, J. D., Wadhawan, Jay   +12 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Urea electrooxidation coupled with energy-saving H2 production using bimetallic sulfide heterojunctions

Electrochemistry Communications
The theoretical electrocatalytic potential for the urea oxidation reaction (UOR) is notably low at 0.37 V, positioning it as a promising alternative to hydrogen evolution reaction for traditional water electrolysis.
Suzhen Bai, Kesheng Cao, Yi Zeng, Zhengshan Tian, Xiangxiang Du, Xingqun Zheng   +5 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source