Results 81 to 90 of about 885,988 (258)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

open access: yesFEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik   +6 more
wiley   +1 more source

Nurses’ Knowledge and Perceived Practices Regarding the Green Hospital at Badr University Hospital [PDF]

open access: yesHelwan International Journal for Nursing Research and Practice
Background: Green hospitals have evolved, emphasizing sustainability through eco-friendly measures, including waste reduction, energy efficiency, and non-toxic materials.
Mustafa Mohamed
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Green Price and Green Place: How Important is Green Consumer Knowledge for Purchasing Sustainable Products?

open access: yesIndonesian Interdisciplinary Journal of Sharia Economics
This study aims to analyze the role of green consumer knowledge in mediating the influence of green price and green place on the purchasing decisions of environmentally friendly AMDK Aqua Life products in Bogor City.
Erlan Herdiatna   +2 more
doaj   +1 more source

Knowledge-Based Green’s Kernel for Support Vector Regression

open access: yesMathematical Problems in Engineering, 2010
<p> This paper presents a novel prior knowledge-based Green's kernel for support vector regression (SVR). After reviewing the correspondence between support vector kernels used in support vector machines (SVMs) and regularization operators used in regularization networks and the use of Green's function of their corresponding regularization ...
Farooq, Tahir   +2 more
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Harnessing knowledge management for green product competitive advantage with green process innovation as a mediator

open access: yesJournal of Open Innovation: Technology, Market and Complexity
Knowledge Management makes businesses sustainable and enhances their competitive edge. Therefore, this study aims to investigate the relationship between knowledge management and green product competitive advantage through the mediating role of green ...
Saqib Rehman   +4 more
doaj   +1 more source

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