Results 111 to 120 of about 3,304,021 (293)
The productivity and energetic efficiency of cultivation of sainfoin varieties
Зерновое хозяйство России, 2018 The decision of the problem of the development of the stable forage production without increasing of the areas with legumes is considered impossible. The creation of a stable fodder base for animal husbandry in the most soil-climatic zones of the country
S. A. Ignatiev +3 more
doaj +2 more sources
Зерновое хозяйство России, 2018 Due to the increasing aridity during the vegetation, productivity of fodder crops is unstable in the last years, and does not meet the cattle needs in rich feed.
S. I. Gorpinichenko +3 more
doaj
UV and radiofrequency observations of Wolf-Rayet stars [PDF]
Observations of W stars in the ultraviolet by OAO 2 and at 750 and 1400 MHz with the Green Bank telescopes are discussed. The emphasis is on the Green Bank observations of W stars with symmetric nebulae around them, their interpretation, and comparisons ...
Johnson, H. M.
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
ФАКТОРЫ ПОВЫШЕНИЯ ИНТЕНСИВНОСТИ РОСТА РЕМОНТНЫХ СВИНОК И ВОСПРОИЗВОДИТЕЛЬНЫХ СПОСОБНОСТЕЙ СВИНОМАТОК
Ветеринарная патология, 2010 The optimal structure of diets in growing replacement gilts from 30 kg to fertilization and the effect of different proportion of green and succulent feed on the reproductive capacity of sows.
doaj
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source