Results 121 to 130 of about 3,305,992 (292)
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Greenness metrics for analytical methodologies linked to mass spectrometry
Green Analytical ChemistryWith a global focus on sustainability and environmental impact, scientists have been prompted to adopt eco-friendly practices. Green analytical chemistry (GAC) promotes energy-efficient equipment, reduction of toxic chemicals, and sustainable waste management.
Marina Jurisch +7 more
openaire +2 more sources
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
FIELD EXPERIMENTS OF EFFICIENT USE OF FERTILIZER GUMISTIM ON MAIZE
Зерновое хозяйство России, 2018 The article considers the study results of the efficiency of organic fertilizer Gumistim for seeds and plants of maize. Three doses of the drug for seed processing have been studied and the optimal one has been established.
I. A. Shmalko, V. N. Bagrintseva
doaj +2 more sources
Tilling capacity as an element of Sudan grass productivity
Аграрная наука Евро-Северо-ВостокаThe physiological bases for Sudan grass tilling capacity and methods for its regulation have not been sufficiently studied, since this trait is affected by both a genotype and the environment.
N. A. Kovtunova +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Аграрная наука Евро-Северо-ВостокаThe research was carried out in 2022-2024 in order to evaluate 18 promising hulled and naked oat genotypes according to grain yield and grain mass and to identify the mowing and universal genotypes with high plasticity and stability in the conditions of ...
E. N. Vologzhanina
doaj +1 more source