Results 11 to 20 of about 82,086 (215)

Damage Identification of Gas Station Double Layer Grid Structure Based on Time Domain Response Sensitivity Analysis

Buildings
Gas station canopy grid structures develop local damage during service life, necessitating regular inspection and maintenance to prevent structural collapse.
Yan Wang, Yan Shi, Tao-Yuan Yang, Wei-Nan Wang, Yu-Qi Zhang, Wei Xi   +5 more
doaj   +1 more source

Uniaxial Compression Response and Instability Mechanisms of Parallel Dual Coal Pillar–Roof Combinations

Geofluids
The remaining coal pillars and roof form an integral coal pillar–roof system (CPRS) that plays an important role in the safety of the room mining goaf.
Jingkai Li, Chunge Li, Shengjian Zhao, Changde Yang, Kun Niu, Quancai Ji, Zhiqiang Wang   +6 more
doaj   +1 more source

Study of high-resolution analysis of Rayleigh waves on the basis of the Choi–Williams distribution

Frontiers in Earth Science
Rayleigh wave exploration is widely used in the field of engineering investigation, which can analyze the near surface velocity structure. However, the traditional Rayleigh wave exploration data processing method can only provide the average change of ...
Min Xiang, Min Xiang, Xuhui Zhang, Xuhui Zhang, Yuxuan Wei, Xiaoyong Yao, Xiaoyong Yao   +6 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Initial pore distribution characteristics and crack failure development of cemented tailings backfill under low impact amplitude

Frontiers in Earth Science, 2023
The stability of the cemented paste backfill is threatened by the dynamic disturbance during the excavation of the surrounding ore body. In this paper, the computerized tomography (CT) and Split Hopkinson Pressure Bar (SHPB) tests were conducted to ...
Di Zheng, Di Zheng, Guangsheng Liu, Guangsheng Liu, Lijie Guo, Lijie Guo, Xiaocong Yang, Xiaocong Yang, Shan Wu, Shan Wu, Yue Zhao, Yue Zhao   +11 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Analysis of the Correlation Between Factors Affecting Green Mining in Open-Pit Mines

Energy Exploration & Exploitation
Green mining is of great significance for the sustainable development of mines. However, the current green mine evaluation index system proposed in China is complex, and the intrinsic logical relationships between the indicators are not yet clear.
Yiyuan Cui, BinBin He, Kun Li, Yaoxuan Li   +3 more
doaj   +1 more source

Structural Viability and Design Methodology of Bio-Based Concrete Panels in Modern Prefabrication

Buildings
The incorporation of agricultural waste into construction materials represents a promising pathway toward achieving carbon neutrality in the building sector.
Wei Xi, Wei-Nan Wang, Yan Wang, Tao-Yuan Yang   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source