Results 21 to 30 of about 2,418,377 (304)

Lost-ore mining—A supplementary mining method to sublevel caving [PDF]

, 2023
Sublevel caving (SLC) is a mass mining method having high productivity and high safety. However, this method often causes a considerable amount of permanent ore loss. Interestingly, all lost ores are buried in the broken waste rocks that come mostly from
Zhang, Zong-Xian, Zong-Xian Zhang
core   +1 more source

Study of high-resolution analysis of Rayleigh waves on the basis of the Choi–Williams distribution

Frontiers in Earth Science
Rayleigh wave exploration is widely used in the field of engineering investigation, which can analyze the near surface velocity structure. However, the traditional Rayleigh wave exploration data processing method can only provide the average change of ...
Min Xiang, Min Xiang, Xuhui Zhang, Xuhui Zhang, Yuxuan Wei, Xiaoyong Yao, Xiaoyong Yao   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Weka: A machine learning workbench for data mining [PDF]

, 2005
The Weka workbench is an organized collection of state-of-the-art machine learning algorithms and data preprocessing tools. The basic way of interacting with these methods is by invoking them from the command line.
Pfahringer, Bernhard, Hall, Mark A., Kirkby, Richard Brendon, Holmes, Geoffrey, Witten, Ian H., Frank, Eibe   +5 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Analysis of the Correlation Between Factors Affecting Green Mining in Open-Pit Mines

Energy Exploration & Exploitation
Green mining is of great significance for the sustainable development of mines. However, the current green mine evaluation index system proposed in China is complex, and the intrinsic logical relationships between the indicators are not yet clear.
Yiyuan Cui, BinBin He, Kun Li, Yaoxuan Li   +3 more
doaj   +1 more source

Structural Viability and Design Methodology of Bio-Based Concrete Panels in Modern Prefabrication

Buildings
The incorporation of agricultural waste into construction materials represents a promising pathway toward achieving carbon neutrality in the building sector.
Wei Xi, Wei-Nan Wang, Yan Wang, Tao-Yuan Yang   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Coal wall bending calculation and spalling risk classification using Chebyshev polynomials

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
In view of the severe constraints of coal wall spalling and roof caving problems on the productivity release and intelligentization process of large mining height working faces, this paper comprehensively analyzes the key factors affecting coal wall ...
Zhining Zhao, Weidong Pan, Baiyu Hu, Guocheng Zhang, Cang Deng, Xiyuan Qin, Yupei Deng   +6 more
doaj   +1 more source