Results 81 to 90 of about 462,069 (303)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The impact of noise on green open space value

Journal of Environmental Management
I investigate the effect of noise on the amenity value of urban green open spaces in Prague, Czech Republic. First, I use standard hedonic pricing model exploiting cross-sectional and quasi-experimental variation in the apartment price data and then I analyse green open spaces quality inferred from a quantitative spatial model.
openaire   +2 more sources

A Study on the Structures of Green, Open Space in Urbanization of Green Zone

Journal of the Japanese Institute of Landscape Architects, 1983
市街地における緑地環境は地域的にさまざまな様相を呈している。この実態を市街化過程との関連でとらえるべく, 東京効外にかつて指定された緑地地域のその後の変遷について, 主としてその解除に際していかなる配慮がなされたか, また解除後の市街地の形成過程においていかなる緑地環境か形成されてきたか, 二, 三の事例を検討しながら緑地環境形成にかかわる課題について整理することを試みたものである。
openaire   +2 more sources

Healing Garden as a Green Open Space in Hospital

International Islamic Medical Journal
Introduction: Natural environments within healthcare settings have received growing interest for their potential role in supporting health and well-being. Healing gardens are typically green open spaces within hospitals that promote the physical, mental, and emotional rehabilitation of patients, also benefiting the staff and visitors.
Marselli Widya Lestari, Anisgupta Larasaty Favurita   +1 more
openaire   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

MANAGEMENT OF GREEN OPEN SPACE GREEN OPEN SPACE MANAGEMENT ON THE MAKASSAR CITY INDEPENDENCE PIONEER ROAD CORRIDOR

 Abstract This research aims to develop principles, develop innovations, and develop these in the arrangement of green open spaces. The type of research used is qualitative and descriptive quantitative research. In this study, the condition of the road median and the level of tree/plant damage were measured directly, while the community's aspirations ...
Giska Putri Lestari, Arifuddin Akil, Andi Bachtiar Arief   +2 more
openaire   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Pengembangan Aplikasi Partisipatif Ruang Terbuka Hijau Wilayah Provinsi Jawa Barat

Rekayasa Hijau: Jurnal Teknologi Ramah Lingkungan, 2018
ABSTRAK Proporsi Ruang Terbuka Hijau (RTH) pada suatu wilayah ditargetkan minimal 30% dari luas wilayah kota. Kenyataannya pemerintah kabupaten/kota di Provinsi Jawa Barat belum ada yang dapat memenuhi target tersebut.
- Sumarno, - Indrianawati
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

New Urban Governance in Controlling Public Green Open Spaces in Indonesia [PDF]

E3S Web of Conferences
This study aims to describe how new urban governance controls public green open spaces in Indonesia. Cities in Indonesia experience an imbalance of public green open space that must be provided.
Sulistyaningsih Tri, Sunarto, Kulsum Umi
doaj   +1 more source