Results 91 to 100 of about 14,425,722 (316)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Developing green guidance practice: Report from the innovation factories [PDF]

This report presents the outcomes of a series of innovation factories which were held in Czechia, Norway, Poland, Portugal and Slovakia to develop practical approaches to green guidance.
Wrzosek, M., Hooley, T., Przybysz, I., Bakke, I.B., Košťálová, H., Ostroha, L., Stano, K, Kavková, E., Lucas Casanova, M., Šprlák, T.   +9 more
core  

Community Green Map Detroit

, 2003
A map of a small area of Detroit done by children, which includes descriptions and photographs of the community gathering that produced the ...
Detroit Green Map Team
core   +1 more source

Social innovation: the process development of knowledge-intensive companies [PDF]

, 2012
The new service development of knowledge-intensive companies in emerging economies is changing from processes with only economic goals to processes that combine economic and social needs.
Sandro Battisti, Battisti, Sandro
core   +1 more source

Perinatal exposure to 4-hydroxy-4′-isopropoxydiphenylsulfone alters the adipogenesis in adult mice: A sex-specific study

Ecotoxicology and Environmental Safety
4-hydroxy-4′-isopropoxydiphenylsulfone (BPSIP), a common alternative to bisphenol A (BPA), has been detected in breast milk and across placental barriers. However, the long-term impacts of perinatal exposure to BPSIP on adipogenesis and susceptibility to
Shengnan Zhang, Jiatong Shen, Kaini Hu, Yitong Zhou, Yumeng Wang, Xin Wang, Kashif Hayat, Mingrong Qian   +7 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Managing the complexity of green innovation

, 2022
Purpose Green innovation can promote both environmental sustainability and economic growth. However, its development and implementation can be complex due to the need to align innovation activities within and across companies. In this study, the authors
Sukhov, Alexandre, Abadzhiev, Andrey,, Johnson, Mikael, Sukhov, Alexandre,, Johnson, Mikael,, Sihvonen, Antti, Abadzhiev, Andrey, Sihvonen, Antti,   +7 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

INFLUENCE OF COMPETITION INTENSITY ON GREEN PROCESS INNOVATIONS AND GREEN PRODUCT INNOVATIONS AND ITS IMPACT ON ENVIRONMENTAL PERFORMANCE

, 2022
Abstarct Organizations adopting green practices can position themselves distinctively in the competitive marketplace and get the potential competitive advantage over competitors. If a market has characterised by intense competition, customers have many alternative options to satisfy their needs and can easily switch to other suppliers.
openaire   +1 more source