Results 101 to 110 of about 14,425,722 (316)
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Sustainability in organizations is one of the most persistent issues for ecologists and business managers today. The emerging urgency of environmental sustainability has compelled organizations to adopt green innovation practices aimed at balancing ecological responsibility with performance outcomes.
null Sadia Shaikh +2 more
openaire +1 more source
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
The integration of new technologies : the stakes of knowledge [PDF]
In order to remain competitive in an increasingly competitive international context, French companies are forced to follow one or more of various possible routes: relocating some of the activities, optimizing the design and / or production process, or ...
AOUSSAT, Améziane +7 more
core +1 more source
A map detailing the sites of interest and importance in the Prospect, NC, and the Robeson County area of North Carolina.
Robeson County Green Map Project
core +1 more source
Spatial biology in cancer epigenetics
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Encouraging innovation activity: in the specific context of small- and medium-sized retailers [PDF]
This paper aims at formalizing an innovation process well suited for small- and medium-sized enterprises (SMEs) specialized in retail. The design research consisted in analyzing conceptual models of innovation process from the literature and adapting it ...
BUISINE, Stéphanie +3 more
core +1 more source
Sustainable practices through green innovation have become key while the organization aims to achieve COP26 (Conference of the Parties, 26th Summit) targets.
Liu Li +2 more
doaj +1 more source
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source

