Results 41 to 50 of about 199,661 (307)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Greening procurement: Exploring evolving practices in an Irish university

Heliyon, 2023
Including green criteria in the public procurement of goods and services requires increased expertise, new methodologies, more significant monitoring efforts and more support towards innovation.
Alexandra Revez, Maria Kirrane, Fiona Thomson   +2 more
doaj   +1 more source

Sustainability best practice in PPP: Case study of a hospital project in the UK [PDF]

, 2013
Globally, sustainable development has been given high priority for the Government agenda in order to achieve a balance of social, economic and environmental factors.
Smith, Andrew James, Zhou, Lei
core  

Effects of Green Supply Chain Management on Organizational Productivity: A Survey of Textile Industries in Eldoret [PDF]

, 2016
Green Supply Chain Management practice is a multi-dimensional concept which can be measured from different perspectives. The study purpose was to assess effects of green supply chain management on organizational productivity: a survey of Textile ...
Ayuma, C. (Caroline), Kebenei, P. (Prudence), Kimutai, G. (Geoffrey)   +2 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Lessons from Canada for green procurement strategy design

Discover Global Society
We derive lessons for green public procurement (GPP) by examining it in the context of Canadian federal government expenditures in several sectors. These show that successful GPP is neither simple nor automatic but requires alignment of green policy ...
A. Migone, M. Howlett, A. Howlett
doaj   +1 more source

Evaluation on the Effectiveness of Green Procurement for attainment of Sustainability.

International Journal of Sustainability in Business and Economics
This study analyses the effects of green procurement practices on sustainability based on a case study of five manufacturing companies in Zimbabwe. A pragmatic approach ie primary and secondary data was used. The research evaluated the current practices,
Evelyn Kumbirai Tapfuma, Simbarashe Dadirai   +1 more
doaj   +1 more source