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ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

Advanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao, Xing‐Rui Cao, Bai‐Qiang Li, Fu‐Ying Zhao, Jia‐Mei Wang, Rui‐Kang Gao, Zhi‐Peng Cao, Zhen‐Xian Du, Hua‐Qin Wang   +8 more
wiley   +1 more source

The environmental elephant in the office: medications. [PDF]

Can Fam Physician
McDermott E, Halil R, Nash WS, Douglass RJ, Train A, Zvereva E, Kandasamy S, Zahid D, Sergeant M.   +8 more
europepmc   +1 more source

Two-Needle Approach to Replenish an Empty Intrathecal Pump. [PDF]

Cureus
Kent A, Dua A, Singh P, Dua A, Sun Z.
europepmc   +1 more source

Effects of Thermal Damage on Impact Response Characteristics of High-Energy Propellants. [PDF]

Polymers (Basel)
Guo F, Nie J, Zhang S, Liang J, Liu R, Zou Y, Han Y.   +6 more
europepmc   +1 more source

Climate change and primary care: how to reduce the carbon footprint of your practice. [PDF]

Br J Gen Pract
Naughton M, Round T, Payne R.
europepmc   +1 more source

Cryogenic propellant management in space: open challenges and perspectives. [PDF]

NPJ Microgravity
Simonini A, Dreyer M, Urbano A, Sanfedino F, Himeno T, Behruzi P, Avila M, Pinho J, Peveroni L, Gouriet JB.   +9 more
europepmc   +1 more source

Use of Luminescence Modulation in a New Series of Mixed Lanthanide Metal-Organic Frameworks for Selective Firearm Ammunition Marking. [PDF]

ACS Omega
De Oliveira Silva JP, Colaço MV, de Resende Camara A, Pereira RA, Fernandes EO, Canuto CC, Carvalhosa DR, Marques LF.   +7 more
europepmc   +1 more source

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Making Progress Towards «Green» Propellants

Propellants, Explosives, Pyrotechnics, 2018
AbstractStabilisers are used in propellants to prevent the various effects such as oxidation, chain scission, energy loss and uncontrolled heat generation that are caused by homolytic and heterolytic cleavage of the weakest Nitrogen‐Oxygen bond of the nitrate ester functional group.
Alain Dejeaifve, André Fantin, Lara Monseur, Rowan Dobson   +3 more
openaire   +1 more source

Green Propellant Infusion Mission Program Overview

49th AIAA/ASME/SAE/ASEE Joint Propulsion Conference, 2013
The NASA Space Technology Mission Directorate’s (STMD) Green Propellant Infusion Mission (GPIM) Technology Demonstration Mission (TDM) is comprised of a cross-cutting team of domestic spacecraft propulsion and green technology experts. The GPIM program has technology infusion-team members from all three major market sectors: Industry, NASA, and the ...
John Yim, Brian Reed, Christopher H. McLean   +2 more
openaire   +2 more sources