Results 131 to 140 of about 1,160,758 (310)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

What America Needs to Know About Higher Education Redesign [PDF]

, 2014
Finding ways to help more Americans develop and connect their knowledge, skills, and talent with a good job may be the most important economic and human development challenge in this country.

core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Foundations for a green economy: how institutions shape green skills

npj Climate Action
Policymakers, companies, trade unions, and civil society actors increasingly recognize the urgent need to facilitate the transition to a low-carbon economy. This Perspective highlights the critical role of “green skills” in this transition.
Marius R. Busemeyer, Martin B. Carstensen, Achim Kemmerling, Jale Tosun   +3 more
doaj   +1 more source

Briefing paper 'On the European workforce for health' [PDF]

, 2009
A critique of the EC report 'On the European Workforce for Health', together with workshop ...
Lethbridge, Jane
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Schools for a sustainable future. Improving green skills in the ESL classroom

RATE Issues
This paper aims to point out the importance of green skills within education, particularly in ESL contexts. It highlights the urgency of addressing environmental challenges such as pollution, deforestation, and climate change, and emphasizes the role of ...
Ildikó Molnar
doaj  

Green Skills for Sustainability Transitions

Geography Compass
ABSTRACT Green Skills are considered a prerequisite for sustainability transitions. However, existing literature shows heterogenous meanings of Green Skills, which are based on normative assumptions about what is understood as ‘green’ and ‘skill’.
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The incidence and intensity of employer-provided training [PDF]

, 2009
This paper examines the provision of training by employers and the participation in training by employees, conditional on employers´ training provision. Together these two dimensions of training determine its overall distribution in the workforce.
Dickerson, A., Wilson, R.
core