Results 121 to 130 of about 1,160,758 (310)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Education, Equity and Social Cohesion : A Distributional Model [Wider Benefits of Learning Research Report No. 7] [PDF]

, 2003
This report - the first from the Centre’s comparative strand of research - focuses on the effects of education on social cohesion at the societal level. The research involved two elements.
Green, Andy, Preston, John, Sabates, Ricardo   +2 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Integrating computational thinking and green skills in vocational education through the bridging learning green informatics framework

Discover Education
Vocational education, also known as Technical and Vocational Education and Training (TVET), faces strategic challenges in integrating Computational Thinking (CT) and green skills to prepare a future workforce that is adaptive to emerging technologies ...
Dyah Vitalocca, Amay Suherman, Dedi Rohendi, Cica Yulia, Ade Gafar Abdullah   +4 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Promoting Islamic Value for Green Skill Development in Islamic Vocational High School

Jurnal Pendidikan Islam
Air pollution is a critical issue in Indonesia in 2023, prompting the need to enhance green skills within Vocational High Schools to support a sustainable green economy.
R. Siti Pupu Fauziah, Agustina Multi Purnomo, Uus Firdaus, Asep Bayu Dani Nanyanto, Martin Roestamy   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

GreenCompass - A self-assessment tool for fostering integration of green skills

Proceedings (European Academy of Sciences and Arts)
In today's ever-evolving landscape, fostering green skills emerges as a paramount endeavour, a beacon of progress towards a green(er) future. Within this transformative journey, this paper unveils a blueprint for organizations and institutions seeking ...
Bojan Jovanovski, Ahm Shamsuzzoha, Radmil Polenakovikj, Mila Velkovska, Trajce Velkovski   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Green economy in the wastewater treatment sector: Jobs, awareness, barriers, and opportunities in selected local governments in South Africa

Journal of Energy in Southern Africa, 2018
The green economy (GE) has increasingly gained international focus, with new strategies aimed at restructuring the economy in an environmentally friendly manner.
Benton Otieno, Aoyi Ochieng
doaj