Results 101 to 110 of about 264,624 (301)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Becoming one with the community: a grounded theory-derived context-specific framework exploring AIDS service organization strategies for implementing pre-exposure prophylaxis outreach among African American populations

BMC Health Services Research
Background Although pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention approach, uptake remains low among African American individuals within the United States (US).
Suur D. Ayangeakaa, Jeanelle S. Sears, Lesley M. Harris, Ryan M. Combs, Kimberly A. Parker, Jelani C. Kerr   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

ZELENÁ SOCIÁLNA PRÁCA AKO ODPOVEĎ NA GLOBALIZÁCIU / GREEN SOCIAL WORK AS A RESPONSE TO GLOBALIZATION

, 2023
Zuzana Strculová
openalex   +2 more sources

GREEN SOCIAL WORK AND COMMUNITY RESILIENCE

TEME
Consumerist culture, industrially oriented societies, and urban lifestyles have led to profound changes in the environment, resulting in climate change and natural disasters. The negative aspects of the ecological crisis are closely linked to the social functioning of individuals, causing issues in physical and mental health, housing, material security,
openaire   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Green social cooperatives in Italy: a practical way to cover the three pillars of sustainability?

Sustainability: Science, Practice, & Policy, 2012
This article provides an introductory description of Italian green social cooperatives which are democratic nonprofit organizations specializing in the provision of environmental services.
Giorgio Osti
doaj  

Green Initiatives in Pakistani Universities: Nexus among Human Resource Practices, Employee Environment Behavior, and Innovative Work with Mediating Role of Work Engagement in Pakistani Universities

Business Review
This study aims to develop a model based on social exchange theory (SET) to elucidate the influence of green human resource management (GHRM) on employee on-the-job, off-the-job, and green innovative work behaviors (GIWB).
Kifayat Ali Larik , Marvi Mangi, Shah Imran Ahmed   +2 more
doaj   +1 more source