Results 121 to 130 of about 2,246,750 (309)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Basisbanen van S-p-a [PDF]

, 2018
The proposal by the Flemish socialist party S-p-a to secure paid jobs for all unemployed, was critized in the media because too expensive.However the government has heavily subsidized businesses; corporations and shareholders now have billions of cash ...
Roels, Frank
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Green social cooperatives in Italy: a practical way to cover the three pillars of sustainability?

Sustainability: Science, Practice, & Policy, 2012
This article provides an introductory description of Italian green social cooperatives which are democratic nonprofit organizations specializing in the provision of environmental services.
Giorgio Osti
doaj  

Green Initiatives in Pakistani Universities: Nexus among Human Resource Practices, Employee Environment Behavior, and Innovative Work with Mediating Role of Work Engagement in Pakistani Universities

Business Review
This study aims to develop a model based on social exchange theory (SET) to elucidate the influence of green human resource management (GHRM) on employee on-the-job, off-the-job, and green innovative work behaviors (GIWB).
Kifayat Ali Larik , Marvi Mangi, Shah Imran Ahmed   +2 more
doaj   +1 more source

CLIMATE CHANGE, GENDER AND GREEN SOCIAL WORK

American International Journal of Humanities, Arts and Social Sciences
Climate change, recognized by the United Nations as a critical challenge of the 21st century, disproportionately impacts poor and marginalized communities, particularly women. These women, often responsible for managing households and supporting their families, face heightened vulnerability due to systemic gender inequalities, such as limited access to
openaire   +1 more source

the Green Social Work: Understanding the Impact of Social Work Education on the Environment

International Journal of Social Science Research and Review
      In today's world, green social work is becoming increasingly important as we face significant ecological issues like climate change, pollution, and depletion of resources. Social workers play a vital role in tackling these issues and fostering sustainable practices within their communities.
Blesso J Yesudian Yesudian, K Maheswari
openaire   +1 more source

Necessary Conditions for Improving Civic Competence: A Scientific Perspective [PDF]

Many attempts to increase civic competence are based on premises about communication and belief change that are directly contradicted by important insights from microeconomic theory and social psychology. At least two economic literatures are relevant to
Arthur Lupia
core