Results 91 to 100 of about 133,944 (264)

Residents’ Views and Perceptions for the Use and Design of the Urban Green Infrastructure to the Second Largest Municipality of Metropolitan Area of Thessaloniki

Proceedings
Urban green infrastructure captures an appreciation of urban green as essential infrastructure that is as important to a good quality of urban life as technical or social infrastructures.
Paraskevi Karanikola, Stilianos Tampakis, Aikaterini Karipidou-Kanari, Antonios Tampakis   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

296 Investing in Community-Led Research Capacity Building: New Seed Grant Type

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: We will describe the community-driven development and impact of the new Community Research Capacity-Building grants from the Alliance for Research in Chicagoland Communities, Northwestern University.
Jen Brown, Claudia Galeno-Sanchez, Corella Payne, Sista Yaa Simpson, Priyanka Reddy, Claudia Galeno-Sanchez, Pedro Serrano   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Spatial Heterogeneity Analysis of the Multidimensional Characteristics of Urban Green Spaces in China—A Study Based on 285 Prefecture-Level Cities

Land
Quantitative measurement of urban green spaces (UGSs) plays a fundamental role in enhancing their ecological functions and services. Current studies have not adequately analyzed the multifunctional characteristics and the diverse benefits of urban green ...
Wei Zhao, Dianfeng Liu, Jiqiang Niu, Jianhua He, Feng Xu   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Understanding the gnawing threat of encroachment of urban green spaces in Ghana’s growing urban fabric

Discover Cities
Urban green spaces offer unique social, health, and economic benefits such as sanitizing the air, protecting flora and fauna, and reducing heat waves, ultimately improving life quality.
Benjamin Doe, Prince Aboagye Anokye, Ama Kyerewaa Attakorah, Stephen Biliyitorb Liwur   +3 more
doaj   +1 more source

The unequal contribution of urban blue-green space to the cooling effect

Frontiers in Environmental Science
Clarifying the contribution of urban blue-green spaces to the cooling effect on surface temperature is crucial for rationalizing urban land use and ensuring sustainable urban development.
Xiaoming Li, Chenchen Fan, Xiaohan Sun, Wenwen Li, Jieqiong Lu, Jieqiong Lu, Guanglong Bao, Fei Yan   +7 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source