Results 111 to 120 of about 167,652 (309)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 2020 In recent years, Australian literature has experienced a revival of interest both domestically and internationally. The increasing prominence of work by writers like Christos Tsiolkas, heightened through television and film adaptation, as well as the ...
Stephanie Green, Green, Stephanie
core +1 more source
Regional SustainabilityGreen spaces in urban and suburban areas play a significant role in helping settlements adapt to climate change. The design, quantity, quality, and location of green spaces influence their ability to provide benefits to people and enhance the quality of ...
Tamás Hardi +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Environmental Justice in Accessibility to Green Infrastructure in Two European Cities
Land, 2018 Although it is well-established that urban green infrastructure is essential to improve the population’s wellbeing, in many developed countries, the availability of green spaces is limited or its distribution around the city is uneven.
Catarina de Sousa Silva +3 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Perception and use of various urban green spaces in Padova (Northern Italy)
, 2018 Urban green spaces are a focal area for the daily life of citizens. Therefore, deep knowledge of citizens’ perceptions and uses of green infrastructures is crucial in urban planning and design.
Arne Arnberger +8 more
core
Green open spaces: climate mitigation of climate change in Indonesia
Introduction: The provision of microclimate for young people is an important prerequisite for outdoor thermal comfort in urban communities. The microclimate consists of four elements: air temperature, humidity, wind speed and solar radiation.
Agus, Fadilatur Rahmi, Ismail, Yunita
core +1 more source