Results 121 to 130 of about 7,189,249 (350)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Benefits of urban green spaces in noise, air quality and thermal comfort: the case study of Bragança [PDF]
, 2010 Urban green areas provide multiple environmental services, contributing to high‐quality environments in our cities. With the purpose of evaluating the influence of urban green spaces in air quality, noise and thermal comfort, a research was developed ...
Feliciano, Manuel +3 more
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, 2020 Urban green spaces provide a range of environmental and health benefits, which may become even more critical during times of crisis such as the current COVID-19 pandemic.
Bianca E. Lopez +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Ett sociotopkarteringsarbete i Länghem – En studie i hur invånarna använder och värderar grönytor [PDF]
, 2017 This essay examines how the inhabitants in the village of Länghem in the Tranemo municipality uses and valuates green areas. The municipality of Tranemo is currently working on a in depth comprehensive plan for Länghem and is therefore in need of a ...
Larsson, Marcus, Persson, Emma
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Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Urban Green Spaces and Their Need in Cities of Rapidly Urbanizing India: A Review
Urban Science, 2019 Urbanization offers several opportunities for the growth of economic, social, and technology sectors, offering benefits to society in terms of better living and healthcare facilities, as well as employment opportunities.
M. Ramaiah, R. Avtar
semanticscholar +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
The Economic Impact of the Redevelopment of Georgetown, Connecticut: The Former Gilbert and Bennett Wire Mill, Main Street, and Old Mill Road [PDF]
Redevelopment of old mill creates vibrant new spaces, preserves green space, creates densitydevelopment ...
Brian Baird, Stan McMillen
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