Results 91 to 100 of about 2,585,989 (270)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The Influence of Green Transformational Leadership, Green Training, and Competency for Employee Performance

Indikator: Jurnal Ilmiah Manajemen dan Bisnis
Abstract. This study aims to analyze the effect of Green Transformational Leadership, Green Training and Competence on Employee Performance on employees of PT Bumi Berkah Boga. The objects in this study are employees of PT Bumi Berkah Boga with various ages who have worked in the company for a span of one to three years of work, domiciled in ...
Robbi Robbi, Sri Anah
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

On charisma and need for leadership [PDF]

Some scholars have argued and found that the relationship between transformational leadership and outcomes can be moderated by subordinate or situational characteristics (e.g. Bass and Avolio, 1990; Podsakoff, MacKenzie, and Bommer, 1995).
Roe, R.A., Vries, R.E. de, Taillieu, T.C.B.   +2 more
core  

Green Transformational Leadership, Organizational Commitment and Green Human Resource Management on Green Innovation Performance at the Government Sector

Purpose – The rapid growth of government and business sectors, organizations are always required to create various innovations, especially environmentally friendly innovations, in their human resources.
Asep Rokhyadi Permana SAPUTRA, Yunita RAHMADANI, Sri Muliati ABDULLAH   +2 more
core   +1 more source

Green Transformational Leadership and Its Impact on Sustainable Performance in Manufacturing Companies: The Role of Organizational Support and Human Resource Management [PDF]

مطالعات مدیریت توسعه سبز
In recent years, escalating environmental crises have prompted a worldwide commitment to sustainable business practices, with the adoption of green initiatives and strategies emerging as a key solution.
Hossein Jamali, Mehdi Kabiri Naeini, Zeynab Elahi   +2 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Green transformational leadership and firm reputation: the roles of green supply chains and individual green values using Structural Equation Modeling

Cogent Business & Management
This study examines how green transformational leadership, individual green values, and green supply chain management influence corporate reputation in the Peruvian food sector.
Nicolay Alexander Galecio Sosa, Ruben Guevara   +1 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source