Results 171 to 180 of about 60,764 (306)

The Greenery of City Parks

Journal of the Japanese Institute of Landscape Architects, 1966
Tomoo OZAMA, Hiroko KUBOTA
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Health of teleworkers: a scoping review on the assessment of the work-from-home environment. [PDF]

J Occup Health
Oda M, Yoshimori Y, Yamada T, Amagasa S, Fukuda Y.   +4 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

An observational feasibility study on the impact of green exposure on major depressive episode symptomatology and inflammatory biomarkers. [PDF]

Front Psychiatry
Pavarino G, Brasso C, Boido M, Carluccio A, Cirulli F, Mengozzi G, Schellino R, Vercelli A, Rocca P.   +8 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Quantifying inner corridor space design elements for embedded retirement facilities based on eye-tracking. [PDF]

Sci Rep
Fu G, Zhang X, Jiang Y, Zhang D.
europepmc   +1 more source

The modern idea of park and the formation of urbanism in São Paulo: Der Städtebau and the British Town Planning Reception [PDF]

, 2008
Lemes, Fabiano
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

From images to health insight: integrating MLLM, NLP, and objective Q-sorting of nursing-home built environment orientations. [PDF]

Front Med (Lausanne)
Li SJ, Zou ZJ, Ye X, Lin C.
europepmc   +1 more source