Results 111 to 120 of about 54,439 (256)

Improving the Assessment of the Environmental Indicators of Investment Projects Based on the Public-Private Partnership

open access: yesBaltic Journal of Real Estate Economics and Construction Management, 2015
Implementation of environmentally significant activities is often associated with the need to attract significant investment from different sources, both public and private.
Malakhova Tatiana N.   +2 more
doaj   +1 more source

Green heritage, green history and green planning

open access: yes, 2021
The value of historical districts, especially in large urban contexts, is a complex issue. The theoretical debate on the extension of the heritage concept goes back to the International Conventions of The Hague (1954) and Paris (1972) and, in Italy, to the Franceschini Commission of Inquiry, and has recently even reached the hypothesis of "tout ...
Nerantzia Tzortzi, Maria Stella Lux
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Arctic greening associated with lengthening growing seasons in Northern Alaska

open access: yesEnvironmental Research Letters, 2019
Many studies have reported that the Arctic is greening; however, we lack an understanding of the detailed patterns and processes that are leading to this observed greening.
Kyle A Arndt   +8 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Greening IT : How greener it can form a solid base for a low-carbon society [PDF]

open access: yes, 2010
272 p.Libro ElectrónicoInformation Technology is responsible for approximately 2% of the world's emission of greenhouse gases. The IT sector itself contributes to these greenhouse gas emissions, through its massive consumption of energy - and therefore ...

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Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Holly Sue Greening Oral History Interview

open access: yes, 2015
Holly Sue Greening, Executive Director of the Tampa Bay Estuary Program, grew up on the east coast of Florida. Inspired as a child by ichthyologist Dr.
Greening, Holly Sue   +3 more
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