Results 131 to 140 of about 61,618 (305)
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Greening textile industry in Vietnam [PDF]
, 2011 The textile and garment industry has made a remarkable contribution to the economic development of Vietnam and employs currently a large labor force of 2.5 million people.However, the textile industry is also seen as a most polluting and ...
Nguyen Thi Phuong, L.
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
The provisions for greenery within high-density central business districts (CBDs) are considerably lower than outside the CBD. The impact of a highly compact urban configuration of medium- to high-rise buildings on the solar gain on street level and a ...
Melsom, J, Makki, M
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Evaluating urban greening scenarios for urban heat mitigation: a spatially explicit approach
Urban green infrastructure, especially trees, are widely regarded as one of the most effective ways to reduce urban temperatures in heatwaves and alleviate the adverse impacts of extreme heat events on human health and well-being.
Joost, Stephane +6 more
core +1 more source
Greening the city: Can the ecological and the human dimensions of the city be part of town planning [PDF]
, 1994 Ideas about green cities have been around for centuries, however it seems that these ideas have been sidetracked by a strange mixture of opposites: neoclassical economics and town planning regulations.
Newman, P., Burke, G., Mouritz, M.
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ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
With the inequalities in accessing urban green space being intensified worldwide, the capitalization of urban green space (UGS) is increasingly becoming an important concern for achieving inclusive and sustainable urban development.
He, Shenjing, Fan, Zhengxi, Shan, Lu
core +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source