Results 181 to 190 of about 2,276,968 (394)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Flowering, forcing, storage and vase life of Hamamelis

European Journal of Horticultural Science, 2009
A. Sæbø, S. O. Grimstad
doaj   +1 more source

O direito internacional do meio ambiente e o greening da Convenção Americana sobre Direitos Humanos

Revista Direito GV
Este artigo tem como objetivo buscar uma breve reflexão sobre as inter-relações entre a proteção internacional do meio ambiente e dos direitos humanos e analisar as contribuições do chamado greening ou "esverdeamento" do sistema interamericano de ...
Valerio de Oliveira Mazzuoli, Gustavo de Faria Moreira Teixeira   +1 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Complexity revealed in the greening of the Arctic

Nature Climate Change, 2019
I. Myers-Smith, Jeffrey T. Kerby, G. Phoenix, J. Bjerke, H. Epstein, Jakob Johan Assmann, C. John, L. Andreu‐Hayles, S. Angers‐Blondin, P. Beck, L. Berner, U. Bhatt, Anne D. Bjorkman, D. Blok, A. Bryn, C. Christiansen, J. Cornelissen, Andrew M. Cunliffe, S. Elmendorf, B. Forbes, S. Goetz, R. Hollister, Rogier de Jong, M. Loranty, M. Macias‐Fauria, K. Maseyk, S. Normand, J. Olofsson, Thomas C. Parker, F. Parmentier, E. Post, G. Schaepman‐Strub, F. Stordal, P. Sullivan, H. Thomas, H. Tømmervik, Rachael Treharne, C. Tweedie, D. Walker, M. Wilmking, S. Wipf   +40 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Greening of the Earth and its drivers

, 2016
Zaichun Zhu, Zaichun Zhu, S. Piao, S. Piao, R. Myneni, Mengtian Huang, Zhenzhong Zeng, J. Canadell, P. Ciais, P. Ciais, S. Sitch, P. Friedlingstein, A. Arneth, C. Cao, Lei Cheng, Etsushi Kato, C. Koven, Yue Li, Xu Lian, Yongwen Liu, Ronggao Liu, J. Mao, Yaozhong Pan, S. Peng, J. Peñuelas, B. Poulter, T. Pugh, T. Pugh, B. Stocker, B. Stocker, N. Viovy, Xuhui Wang, Ying‐ping Wang, Zhiqiang Xiao, Hui Yang, S. Zaehle, N. Zeng   +36 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Opportunities and Challenges of Artificial Intelligence for Green Manufacturing in the Process Industry

, 2019
Shuai Mao, Wang Bing, Yang Tang, Feng Qian   +3 more
openalex   +1 more source

Green synthesis of stretchable ethyl cellulose film plasticized with transesterified sunflower oil

, 2023
Athira Narayanan, Marco Friuli, Alessandro Sannino, Christian Demitri, Leonardo Lamanna   +4 more
openalex   +1 more source