Results 61 to 70 of about 506,324 (223)

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

Molecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran, Clarence Yapp, Gregory J. Baker, Johanna Beyer, Young Hwan Chang, Allison L. Creason, Robert Krueger, Jeremy Muhlich, Nathan Heath Patterson, Kevin Sidak, Damir Sudar, Adam J. Taylor, Luke Ternes, Jakob Troidl, Xie Yubin, Artem Sokolov, Darren R. Tyson   +16 more
wiley   +1 more source

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Green formula in Hall algebras and cluster algebras [PDF]

arXiv, 2008
The objective of the present paper is to give a survey of recent progress on applications of the approaches of Ringel-Hall type algebras to quantum groups and cluster algebras via various forms of Green's formula. In this paper, three forms of Green's formula are highlighted, (1) the original form of Green's formula \cite{Green}\cite{RingelGreen}, (2 ...
arxiv  

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Territorialisation et écologisation dans la filière forêt-bois française : une rencontre fortuite ?

Développement Durable et Territoires, 2020
This article explores the links between relocation and greening processes within the French forest-wood chain. We show that the parallel emergence of both processes led to the legitimization of the territory as a relevant scale for the implementation of ...
Jonathan Lenglet, Sylvain Caurla
doaj   +1 more source

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Spatial heterogeneity of greening and browning between and within bioclimatic zones in northern West Siberia

Environmental Research Letters, 2016
Studies of the normalized difference vegetation index (NDVI) have found broad changes in vegetation productivity in high northern latitudes in the past decades, including increases in NDVI (‘greening’) in tundra regions and decreases (‘browning’) in ...
Victoria V Miles, Igor Esau
doaj   +1 more source

Application of the Theory of Change in the Greening of Business [PDF]

Bìznes Inform
The article summarizes scientific approaches to the development of the theory of changes in the greening of business. The scientific and methodological approaches to understanding the basics of the theory of change have been developed.
Stretovych Oleksandr O.
doaj   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

Arctic greening associated with lengthening growing seasons in Northern Alaska

Environmental Research Letters, 2019
Many studies have reported that the Arctic is greening; however, we lack an understanding of the detailed patterns and processes that are leading to this observed greening.
Kyle A Arndt, Maria J Santos, Susan Ustin, Scott J Davidson, Doug Stow, Walter C Oechel, Thao T P Tran, Brian Graybill, Donatella Zona   +8 more
doaj   +1 more source