Results 91 to 100 of about 368,089 (290)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Urban ScienceUrban green spaces (UGSs) are vital in enhancing environmental quality, social well-being, and climate resilience, yet their distribution and accessibility remain uneven in many rapidly urbanizing cities.
Shruti Ashish Lahoti +6 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Residential greenness: current perspectives on its impact on maternal health and pregnancy outcomes
, 2017 Rachel F Banay,1,* Carla P Bezold,2,* Peter James,1–3 Jaime E Hart,1,3 Francine Laden1–3 1Department of Environmental Health, 2Department of Epidemiology, Harvard T.H.
Banay RF +4 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Going metric--is it for you? : a management model for small product service companies.
, 1982 "June 1982.""Birch & Davis Associates, Inc."Mode of access ...
Birch & Davis Associates. +1 more
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Aim: In this study, we evaluated the greenness and whiteness scores for microextraction techniques usedin therapeutic drug monitoring. Additionally, the cons and pros of each evaluated method and theirimpacts on the provided scores are also discussed ...
Seyed Mosayeb Daryanavard (18176156) +2 more
core +1 more source
Dealing with non-metric dissimilarities in fuzzy central clustering algorithms [PDF]
, 2008 Clustering is the problem of grouping objects on the basis of a similarity measure among them. Relational clustering methods can be employed when a feature-based representation of the objects is not available, and their description is given in terms of ...
Filippone, Maurizio +2 more
core +1 more source
Greenness metrics for analytical methodologies linked to mass spectrometry
Green Analytical ChemistryWith a global focus on sustainability and environmental impact, scientists have been prompted to adopt eco-friendly practices. Green analytical chemistry (GAC) promotes energy-efficient equipment, reduction of toxic chemicals, and sustainable waste ...
Marina Jurisch +7 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source