Results 101 to 110 of about 329,237 (289)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The potential of volatiles from Brassica juncea seeds against grey mould agent Botrytis cinerea and their effect on storage and sensory quality of spinach leaves

Plant Protection Science
The potential use of volatile compounds released from milled seeds of mustard (Brassica juncea cv. Malopolska) obtained from three different companies was tested in in vitro and in vivo experiments for their inhibitory effect on Botrytis cinerea growth ...
Beata Kowalska, Magdalena Szczech, Maria Grzegorzewska, Anna Wrzodak, Kalina Sikorska-Zimny   +4 more
doaj   +1 more source

Menadione Sodium Bisulfite-Protected Tomato Leaves against Grey Mould via Antifungal Activity and Enhanced Plant Immunity. [PDF]

Plant Pathol J, 2021
Jo YS, Park HB, Kim JY, Choi SM, Lee DS, Kim DH, Lee YH, Park CJ, Jeun YC, Hong JK.   +9 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Quality of two table grape guard cultivars treated with single or dual-phase release SO₂ generators

Journal of Applied Botany and Food Quality, 2012
Berries of seeded table grapes (cultivars Napoleón and Aledo) were trimmed in commercial packing houses, inoculated with Botrytis cinerea, packed with single and dual-phase release SO2 pads, and stored for up to four months at 0 ºC and 85±5 % relative ...
J. P. Fernández-Trujillo, J. M. Obando-Ulloa, R. Baró, J. A. Martínez   +3 more
doaj  

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

POSSIBILITIES AND RESULTS OF HARDNESS CONTROL OF CAST IRON CASTINGS BY MAGNETIC METHOD AFTER POLAR MAGNETIZATION

Литьë и металлургия, 2007
The correlation dependence between hardness of castings of high-duty cast irons and grey irons, contents of pearlite in metallic mould of high-duty cast iron and parameters CrH of remanent magnetic induction field over surface of castings after ...
S. G. Sandomirskij, V. L. Tsukerman, L. Z. Pisarenko   +2 more
doaj