Results 101 to 110 of about 105,661 (265)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

A Neural Network-Based Model Predictive Control for a Grid-Connected Photovoltaic–Battery System with Vehicle-to-Grid and Grid-to-Vehicle Operations

Electricity
The growing integration of photovoltaic (PV) energy systems and electric vehicles (EVs) introduces new challenges in managing energy flow within smart grid environments.
Ossama Dankar, Mohamad Tarnini, Abdallah El Ghaly, Nazih Moubayed, Khaled Chahine   +4 more
doaj   +1 more source

Geomag Mimetic Dynamically Reconfigurable POSS Framework Enables Antifatigue Solid Electrolyte Interphases for Lithium Metal Anodes

Advanced Science, EarlyView.
A Geomag‐inspired dynamically reconfigurable POSS framework is constructed to form an antifatigue solid electrolyte interphase (SEI) for lithium metal anodes. The rigid POSS nanocages and reversible hydrogen‐bonded junctions enable adaptive stress dissipation and stable Li+ transport during repeated plating/stripping, thereby suppressing dendrite ...
Tianyi Wang, Wei Gu, Yu Liu, Di He, Zairan Xiao, Zixia Lin, Tao Huang, Jiabao Li, Hui Chong, Yaojie Lei, Xiaobo Zheng, Bing Sun, Guoxiu Wang, Chengyin Wang   +13 more
wiley   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Efficient energy management and cost optimization using multi-objective grey wolf optimization for EV charging/discharging in microgrid

e-Prime: Advances in Electrical Engineering, Electronics and Energy
The depletion of conventional energy sources coupled with the rising demand for electric vehicles (EVs) has significantly underscored the necessity for electric vehicle supply equipment (EVSE) with advanced energy supply management within microgrids ...
Swati Sharma, Ikbal Ali
doaj   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Grid-to-Vehicle (G2V) and Vehicle-to-Grid (V2G) Technologies [PDF]

, 2021
openaire   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Reconstruction of Ultrafine MnS‐Induced Vacancy‐Rich Co9S6.29 Precatalysts in Mesoporous S‐Doped N‐Rich Hollow Carbon Nanotubes Enables Dynamic O‐Vacancy Cycling for High‐Performance Zn‐Air Batteries

Advanced Science, EarlyView.
We develop vacancy‐rich Co9S6.29 precatalysts formed via ultrafine MnS‐induced lattice distortion in mesoporous S‐doped N‐rich hollow carbon nanotubes (CM@SNHCTs). This CM@SNHCT precatalyst is reconstructed into catalytically‐active cathode phases that enable efficient oxygen reduction/evolution reactions (ORR/OER) through dynamic O‐vacancy formation ...
Debarani Devi Khumujam, Saleem Sidra, Ram Babu Ghising, Dong Won Kim, Jong Hui Choi, Gwanho Lee, Benzhi Wang, Hyung Mo Jeong, Sang‐Il Choi, Do Hwan Kim, Jeung Ku Kang   +10 more
wiley   +1 more source