Results 121 to 130 of about 103,769 (307)

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

open access: yesAdvanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen   +16 more
wiley   +1 more source

Predictive modeling of vehicle-to-grid flexibility: A bottom-up approach demonstrated for a case-study in Germany

open access: yesInternational Journal of Electrical Power & Energy Systems
Germany’s energy transition requires substantial energy storage capacity to manage grid stability and renewable energy integration. Conventional storage technologies may face limitations in meeting the projected demand, while the growing battery electric
Samuel Hasselwander   +2 more
doaj   +1 more source

Improving the storage capability of a microgrid with a vehicle-to-grid interface [PDF]

open access: yes, 2014
In the emergent deployment of microgrids, storage systems play an important role providing ancillary services, such as backup power and reactive power support. This concept becomes crucial in the context of microgrids with a high penetration of renewable
Batista, José   +2 more
core  

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

open access: yesAdvanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore   +20 more
wiley   +1 more source

De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

open access: yesAdvanced Science, EarlyView.
Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li   +23 more
wiley   +1 more source

A Neural Network-Based Model Predictive Control for a Grid-Connected Photovoltaic–Battery System with Vehicle-to-Grid and Grid-to-Vehicle Operations

open access: yesElectricity
The growing integration of photovoltaic (PV) energy systems and electric vehicles (EVs) introduces new challenges in managing energy flow within smart grid environments.
Ossama Dankar   +4 more
doaj   +1 more source

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

open access: yesAdvanced Science, EarlyView.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber   +12 more
wiley   +1 more source

Performance Evaluation of PI and Fuzzy Logic Controllers for a Bidirectional Buck-Boost DC/DC Converter in V2G and G2V Applications

open access: yesJournal of Machine Engineering
This paper presents a comparative analysis of a linear proportional-integral controller and a nonlinear fuzzy logic controller for a bidirectional buck-boost converter in onboard chargers for vehicle-to-grid and grid-to-vehicle applications.
Hamza El-Hassouni   +3 more
doaj   +1 more source

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