Results 201 to 210 of about 105,329 (265)

MicroRNA networks associated with skeletal aging and WNT pathway modulation. [PDF]

Calcif Tissue Int
Achudhan D, Monroe D, Dehankar MK, Qin L, Khosla S, Pignolo RJ, Chandra A.   +6 more
europepmc   +1 more source

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Energy, power, and infrastructure demands from electrifying airport ground support equipment at United States airports. [PDF]

Nat Commun
He Y, Kelly K, Jeffers M, Vercellino R, Ge Y, Lunacek M.   +5 more
europepmc   +1 more source

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

GLP-1R-GIPR-PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice. [PDF]

Nature
Liskiewicz D, Novikoff A, Khalil A, Akindehin S, Campbell JE, Candela P, Castelino RL, Coupland C, Culot M, Dodson WS, Douros JD, Embring H, Feuchtinger A, Finan B, Garcia-Caceres C, Gao XB, Gosselet F, Grandl G, Gutgesell RM, Haas DT, Jastroch M, Karaoglu E, Kakimoto P, Kaltenbach AC, Keuper M, Kusminski CM, Leander DC, Liskiewicz A, Liu X, Maity-Kumar G, Martinez SM, Mowery SA, Nogueiras R, Paisley M, Perez-Tilve D, Petersen PSS, Pfluger PT, Prakash S, Steffens S, Cebrian-Serrano A, Tost M, Wean J, Weber C, Yoshida J, Gerhart-Hines Z, Horvath TL, Scherer PE, Seeley RJ, DiMarchi RD, Tschöp MH, Krahmer N, Knerr PJ, Müller TD.   +52 more
europepmc   +1 more source

An AI-Augmented Dataset of Multi-Prototype Electric Vehicle Charging Load Profiles in China. [PDF]

Sci Data
Liu R, Li Y, Guo N, Li D, Qu H, Zhou Z, Guo Y, Yan Z, Liu J.   +8 more
europepmc   +1 more source

Cradle-to-Grave Lifecycle Analysis of U.S. Medium- and Heavy-Duty Vehicle-Fuel Pathways: A Greenhouse Gas Emissions Assessment of Current (2021) and Future (2035) Technologies. [PDF]

Environ Sci Technol
Kelly JC, Elgowainy A, Vijayagopal R, Muratori M, Sutherland I, Borhan H, Kim HC, Alexander M.   +7 more
europepmc   +1 more source

Impact of Cattaneo–Christov Heat and Mass Flux on MHD Hybrid Nanofluid Flow Over an Extending Surface With Convective and Mass Flux Effects

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT This study investigates the flow of a magnetized hybrid nanofluid over a permeable stretching surface. The mass and thermal transport within the system is regulated using the Cattaneo–Christov flux theory. The fluid is additionally subjected to thermophoresis, chemical reaction, Brownian motion, and activation energy effects.
Ebrahem A. Algehyne, Abdul Bariq, Mounirah Areshi, Fahad Maqbul Alamrani, Zehba Raizah, Izharul Haq, Anwar Saeed   +6 more
wiley   +1 more source

Prospecting of Architectural Features Using LiDAR‐UAV Technology, Deep Neural Networks and Visualization Techniques: A Case Study in Kuélap and Cambolín (NW Peru)

Archaeological Prospection, EarlyView.
ABSTRACT High‐resolution and accurate synoptic images of terrestrial topography, even in densely forested areas, have proven valuable for archaeology by enabling the identification and characterization of relief patterns associated with ancient human activities. This study presents a novel approach that integrates digital terrain models (DTMs) obtained
Jhon A. Zabaleta‐Santisteban, Rolando Salas López, Angel J. Medina‐Medina, Katerin M. Tuesta‐Trauco, Abner S. Rivera‐Fernandez, Nerci M. Noriega‐Salazar, José A. Sánchez‐Vega, Teodoro B. Silva‐Melendez, Marlen A. Grandez‐Alberca, Jhonsy O. Silva‐López, Nilton B. Rojas‐Briceño, Manuel Oliva‐Cruz, Alexander Cotrina‐Sanchez, Elgar Barboza   +13 more
wiley   +1 more source

Retraction Note: Neuroprotective effects of the Immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. [PDF]

J Neuroinflammation
Fields JA, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E.   +9 more
europepmc   +1 more source