Results 51 to 60 of about 4,764,688 (397)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Optimized Demand Side Management for Refrigeration: Modeling and Case Study Insights from Kenya
EnergiesAccording to the International Institute of Refrigeration (IIR), 20% of worldwide electricity consumption is for refrigeration, with domestic refrigeration appliances comprising a fifth of this demand.
Josephine Nakato Kakande +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová +11 more
wiley +1 more source
BuildingsCompared to glass fiber-reinforced polymer (GFRP) and carbon fiber-reinforced polymer (CFRP), basalt fiber-reinforced polymer (BFRP) offers distinct advantages, including the relatively lower cost and superior creep resistance.
Sheng-Jie Duan +5 more
doaj +1 more source
Greedy Firefly Algorithm for Optimizing Job Scheduling in IoT Grid Computing
Sensors, 2022 The Internet of Things (IoT) is defined as interconnected digital and mechanical devices with intelligent and interactive data transmission features over a defined network.
Adil Yousif +6 more
doaj +1 more source
Trends in life science grid: from computing grid to knowledge grid [PDF]
BMC Bioinformatics, 2006 Grid computing has great potential to become a standard cyberinfrastructure for life sciences which often require high-performance computing and large data handling which exceeds the computing capacity of a single institution.This survey reviews the latest grid technologies from the viewpoints of computing grid, data grid and knowledge grid.
openaire +3 more sources
Current Limiting Control With Enhanced Dynamics of Grid-Forming Converters During Fault Conditions
IEEE Journal of Emerging and Selected Topics in Power Electronics, 2020 With an increasing capacity in the converter-based generation to the modern power system, a growing demand for such systems to be more grid-friendly has emerged. Consequently, grid-forming converters have been proposed as a promising solution as they are
Mads Graungaard Taul +3 more
semanticscholar +1 more source
The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells
FEBS Open Bio, EarlyView.We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel +8 more
wiley +1 more source
Electric Vehicle Deployment and Integration in the Saudi Electric Power System
World Electric Vehicle Journal, 2022 The demand for electricity in Saudi Arabia has grown in the last few years due to the growth in the economy and the population. The country has invested in many solutions such as promoting renewable energy and shifting to generation mix to respond to ...
Sulaiman A. Almohaimeed
doaj +1 more source