Results 41 to 50 of about 8,474 (251)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

AMESim-based Study on Dynamic Behavior of Gripping Force of Coiled Tubing Injector Head

Shiyou jixie, 2018
Many problems occur in the coiled tubing operation in oil and gas wells, including coiled tubing slipping, slippage and tubing bite, which seriously threaten the safety of the operation and the life of the coiled tubing.
Ma Weiguo, Lu Lei, Wang Gang, Li Jinhong, Mei Xuesong, Yang Yicheng   +5 more
doaj  

An intelligent grasper to provide real-time force feedback to shorten the learning curve in laparoscopic training

BMC Medical Education
Background A lack of force feedback in laparoscopic surgery often leads to a steep learning curve to the novices and traditional training system equipped with force feedback need a high educational cost.
Xuemei Huang, Pingping Wang, Jie Chen, Yuxin Huang, Qiongxiu Liao, Yuting Huang, Zhengyong Liu, Dongxian Peng   +7 more
doaj   +1 more source

The application of an external wrist extension force reduces electromyographic activity of wrist extensor muscles during gripping. [PDF]

, 2004
Contains fulltext : 57998.pdf (Publisher’s version ) (Open Access)STUDY DESIGN: Experimental repeated-measures study. OBJECTIVE: To investigate the effect of different extension forces applied to the palm of the hand on ...
Degens, H., Elk, Niek van, Faes, Miriam, Kooloos, Jan G.M., Lint, J.A. de, Hopman, Maria T.E., Degens, Hans, Hopman, M.T.E., Faes, M.C., Lint, Jan A. de, Elk, N. van, Kooloos, J.G.M.   +11 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Muscle stress generated in the forearm during hand gripping

Journal of Biomechanical Science and Engineering, 2015
The authors proposed an electromyography computed tomography (EMG-CT) method to measure the distribution of muscle activity in the forearm using surface EMG signals from multiple surface electrodes.
Saran KEERATIHATTAYAKORN, Satoshi YAMADA, Shigeru TADANO   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Design and Evaluation of a Novel Instrument Gripper for Handling of Surgical Instruments

Current Directions in Biomedical Engineering, 2021
Introduction: Contaminated surgical instruments are manually prepared for cleaning and disinfection in the reprocessing unit for medical devices (RUMED). Manual labour exposes staff to the risk of infection and is particularly stressful at peak times due
Heibeyn Jan, König Nils, Domnik Nadine, Schweizer Matthias, Kinzius Max, Janß Armin, Radermacher Klaus   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Impact of material characteristics of cloth on the gripping force and performance of finger grippers

Communications in Development and Assembling of Textile Products
With the rising demand for automation and robotization in the textile industry, a variety of gripping solutions for textile materials has been developed in recent years.
Sophie Herz, Yordan Kyosev
doaj   +1 more source