Results 121 to 130 of about 79,883 (290)

The Impact of Grit on Nurses' Job Performance: Evaluating Chained Mediation through Perceived Social Support and Self-Esteem

Journal of Nursing Management
Background Nurses play a critical role in the medical workforce during the COVID-19 pandemic while facing various difficulties and challenges. Grit, social support, and self-esteem are important psychosocial factors influencing job performance.
Xiqin Liu, Jing-Guang Li, Song Wang
semanticscholar   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Alternative Grit Models: Explorations Into the Psychometric Properties of Grit-S and Academic Performance

International Journal of Educational Psychology
Grit, the passion for achieving long-term goals, has been conceived as a two-dimensional construct (Consistency of interest and Perseverance of effort). The construct is well known for its easy measurement and its relationship with performance, including
Miguel Eduardo Uribe-Moreno, Iván Felipe Medina-Arboleda, Alfredo Guzmán-Rincón, Suelen Emilia Castiblanco-Moreno   +3 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Performance asiática moderna en cuerpos latinos. La cultura K-pop en el Noroeste Argentino

, 2019
El movimiento de la cultura popular contemporánea de Corea del Sur (Hallyu) tuvo un gran impacto en toda América Latina, así también en el Noroeste de la Argentina.
Koeltzsch, Grit Kirstin
core   +1 more source

Exercise, grit, and life satisfaction among Korean adolescents: a latent growth modeling analysis

BMC Public Health
Life satisfaction among Korean students is declining substantially, and multifaceted improvement efforts are required. We analyzed longitudinal change trajectories for exercise, grit, and life satisfaction levels among Korean adolescents using latent ...
Myeong-Hun Bae, Xiaoyu Zhang, Je-Seong Lee   +2 more
semanticscholar   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Comparative analysis of 2-year outcomes in GRIT and TRUFFLE trials [PDF]

, 2020
OBJECTIVE: To explore the effect on perinatal outcome of different fetal monitoring strategies for early-onset fetal growth restriction (FGR). METHODS: This was a cohort analysis of individual participant data from two European multicenter trials of ...
for the GRIT Study Group, the TRUFFLE Study Group   +1 more
core  

The mediating effect of growth mindset in the relationship between adolescents’ optimism and grit

Current Psychology
This study investigated the relationship between optimism, growth mindset, and grit among adolescents. In particular, we explored the mediating effect of growth mindset on the relationship between optimism and grit.
Dasol Pyo, K. Kwak, Y. Kim
semanticscholar   +1 more source