Results 81 to 90 of about 177,385 (295)

Nature and timing of Late Mississippian to Mid-Pennsylvanian glacio-eustatic sea-level changes of the Pennine Basin, UK [PDF]

open access: yes, 2012
The Pennine Basin of northern England contains a comparatively complete Serpukhovian– Moscovian succession characterized by high-resolution ammonoid zonation and cyclic paralic sedimentation.
Condon, Daniel J., Waters, Colin N.
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Independent measurement of the top quark mass and the light- and bottom-jet energy scales at hadron colliders [PDF]

open access: yes, 2007
A method for the simultaneous determination of the energy scales for b-quark jets and light jets, the jet energy resolution, and the top quark mass at hadron colliders is presented.
A. Abulencia   +8 more
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

A look at grit: a study about Malaysian technical instructors’ performance retention [PDF]

open access: yes, 2020
The improvement of instructors' professionalism and quality should be prioritised to achieve Malaysia's Education Blueprint 2013-2025 goals. Most previous studies suggest that teacher effectiveness and performance retention could be measured by the ...
Abd Aziz, Azlihan   +4 more
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

Pemberian Grit pada Ayam Buras Memperpanjang Saluran Pencernaan, Menambah Bobot Ampela, dan Bobot Tulang Karkas (PROVISION OF GRIT TO NATIVE CHICKEN IMROVED THE DEVELOMPMENT OF GASTRO INTESTINAL TRACT AND INCREASE CARCAS BONE)

open access: yesJurnal Veteriner, 2015
Commonly, native chicken is raised in an extensive management system. The chickens were free toscavenge in the backyard, and eat a wide variety of feeds including, rice, corn, insects, or even grit.
Cytske Sabuna   +2 more
doaj  

Lepton anomalous magnetic moments from twisted mass fermions

open access: yes, 2014
We present our results for the leading-order hadronic quark-connected contributions to the electron, the muon, and the tau anomalous magnetic moments obtained with four dynamical quarks.
Burger, Florian   +3 more
core   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

open access: yesFEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi   +6 more
wiley   +1 more source

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