Results 191 to 200 of about 2,720 (298)

Revisiting Target‐Aware de novo Molecular Generation with TarPass: Between Rational Design and Texas Sharpshooter

open access: yesAdvanced Science, EarlyView.
TarPass provides a rigorous benchmark for target‐aware de novo molecular generation by jointly evaluating protein‐ligand interactions, molecular plausibility, and drug‐likeness on 18 well‐studied targets. Results show that current models often fail to consistently surpass random baseline in target‐specific enrichment, while post hoc multi‐tier virtual ...
Rui Qin   +11 more
wiley   +1 more source

Huckleberry Habitat and Its Influence on Two Small Populations of Grizzly Bears (<i>Ursus arctos</i>). [PDF]

open access: yesEcol Evol
Teisberg JE   +5 more
europepmc   +1 more source

Spatial variation in grizzly bear diet across British Columbia

open access: yes
Dietary niche variation is a key facet of an animal’s niche and can be a driver of spatial variation in behaviour, population dynamics, and sensitivity to anthropogenic threats.
Van Elslander, Jonathan
core  

Wireless, Adaptable and Fully Implantable Battery‐powered Devices for Optical Stimulation of the Spinal Cord in Small Rodents

open access: yesAdvanced Science, EarlyView.
Current technologies for spinal cord optogenetic stimulation rely on external power sources and face reliability constraints in freely behaving animals. Here, a fully implantable, battery‐powered optoelectronic device is introduced, enabling operation in any selected environment with wireless recharging for months‐long stimulation.
Shahriar Shalileh   +8 more
wiley   +1 more source

Data‐Driven Modeling of Composition–Processing–Microstructure Relations for Recycled Aluminum Cast Alloys

open access: yesAdvanced Science, EarlyView.
Interpretable machine learning reveals how composition and processing govern the formation and microstructural burden of Fe‐rich intermetallic compounds in recycled Al–Si–Fe–Mn alloys. By separating morphology selection from morphology‐conditioned burden partitioning, this framework shows that identical Fe contents can yield different intermetallic ...
Jaemin Wang   +2 more
wiley   +1 more source

Grizzly Bear Optimization, GBGO

open access: yes
This paper proposes a highly innovative meta-heuristic global optimization algorithm, the Grizzly Bear Optimization (GBGO), inspired by the hunting behavior, group collaboration, olfactory memory, and dynamic domain adaptation of grizzly bears.
openaire   +1 more source

Wireless, Deep‐Seeing Smart Pill: A NIR‐II Fluorescence Imaging Capsule Endoscope for Gastrointestinal Cancer

open access: yesAdvanced Science, EarlyView.
A novel near‐infrared‐II fluorescent imaging capsule endoscope that detects specific fluorescence signals above 900 nm enables highly sensitive, targeted imaging of gastrointestinal cancer tissue. This wirelessly powered and magnetically controlled “smart pill” achieves high sensitivity and deep tissue penetration, allowing precise, non‐invasive ...
Weicheng Wang   +10 more
wiley   +1 more source

An Energetic Tradeoff Best Explains Parturition Timing in Grizzly Bears. [PDF]

open access: yesEcol Evol
Costello CM   +14 more
europepmc   +1 more source

Despotism and risk of infanticide influence grizzly bear den-site selection. [PDF]

open access: yesPLoS One, 2011
Libal NS   +4 more
europepmc   +1 more source

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