Results 41 to 50 of about 1,771 (256)
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Grizzly Bear Noninvasive Genetic Tagging Surveys: Estimating the Magnitude of Missed Detections.
PLoS ONE, 2016 Sound wildlife conservation decisions require sound information, and scientists increasingly rely on remotely collected data over large spatial scales, such as noninvasive genetic tagging (NGT). Grizzly bears (Ursus arctos), for example, are difficult to
Jason T Fisher +3 more
doaj +1 more source
Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina +11 more
wiley +1 more source
How much lox is a grizzly bear worth? [PDF]
PLoS Biology, 2012 Using grizzly bears as surrogates for "salmon ecosystem" function, the authors develop a generalizable ecosystem-based management framework that enables decision makers to quantify ecosystem-harvest tradeoffs between wild and human recipients of natural ...
Jonathan Chase
doaj +1 more source
Oryx, 1966 From 1949 to 1960 the barren-ground grizzly bear was totally protected in the Northwest Territories of Canada, with the result that numbers increased and so did their range. But pressure from trappers led in 1960 to an amendment legalising die killing of grizzlies in defence of life or property, and in 1964, despite the views of wildlife biologists and
openaire +1 more source
Grizzly bears, roads, and human-bear conflicts in southwestern Alberta
, 2010 Because most grizzly bear mortalities occur near roads, the Province of Alberta plans to implement gated access management. Little is known about how grizzly bears will respond to road closures because the effects of roads are confounded by habitat and ...
Joseph, Northrup
core +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
Human-Wildlife Interactions, 2019 Erratum to "Conservation of Threatened Canada-USA Trans-border Grizzly Bears Linked to Comprehensive Conflict Reduction".
Michael F. Proctor +6 more
doaj +1 more source
Black Bear Density and Resource Partitioning with Grizzly Bears
, 2017 American black bears (Ursus americanus) and grizzly bears (U. arctos) have similar habitat requirements, relying on seasonally available grasses, forbs, fruiting shrubs and trees, and neonate ungulates.
Loosen, Anne Elizabeth
core +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source