Results 101 to 110 of about 125,919 (301)

The Megaproject of the Central Eurasian Transport Corridor: Analysis of Effectiveness Using the Input–Output Method

Регионология
Introduction. Assessing the macroeconomic efficiency of major infrastructure projects requires methods that take into account multiplier effects in the economy.
Maksim V. Pyataev, Sergey A. Bykadorov, Yulia K. Serkova   +2 more
doaj   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

The Effect of Different Cadence on Paddling Gross Efficiency and Economy in Stand-Up Paddle Boarding. [PDF]

Int J Environ Res Public Health, 2020
Castañeda-Babarro A, Santos-Concejero J, Viribay A, Gutiérrez-Santamaría B, Mielgo-Ayuso J.   +4 more
europepmc   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Gross worker flows in the presence of informal labor markets : the Mexican experience 1987-2002 [PDF]

This paper applies recent advances in the study of labor market dynamics to a representative developing country with a large informal or unregulated sector, Mexico.
Bosch, Mariano, Maloney, William
core  

Uncertainty evaluation and analysis of gross α and gross β determination in new standard examination methods for drinking water

Fushe yanjiu yu fushe gongyi xuebao
Bsaed on the requirements of "Standard examination methods for drinking water — Part 13: Radiological indices" (GB/T 5750.13—2023) as well as domestic and foreign uncertainty assessment guidelines, this paper presents the uncertainty evaluation of ...
XIE Yuhan, QIAN Yuxin, SHI Cen, YIN Liangliang, JI Yanqin   +4 more
doaj   +1 more source

Research Concerning Standard Gross Margin Depending on Yield in Dairy Farming

Scientific Papers Animal Science and Biotechnologies, 2023
The paper aimed to establish gross margin for three levels of milk yield/cow/year under the condition of Romania: V1-4,000 kg, V2-5,000 kg and V3-6,000 kg.
Ion Pirvutoiu, Agatha Popescu
doaj  

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source