Results 91 to 100 of about 1,049,045 (249)

Permafrost Table Temperature (2008–2021) in Deception Island, Antarctica

Geoscience Data Journal
This manuscript presents a comprehensive presentation of ground temperature data collected at 16 nodes of the 121 of the Crater Lake Circumpolar Active Layer Monitoring (CALM) site on Deception Island, Antarctica, from 2008 to early 2022. Each one of the
M. A. dePablo, M. Ramos
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Markedness as figure-ground manipulation: a hypothesis

Cognitive Linguistics
Markedness in language has been a perpetual fascination for linguists of all persuasions, but a unified account of it has proven elusive. In this paper, I propose a figure-ground gestalt (FGG) hypothesis, arguing that markedness is a mechanism for ...
Chen Rong
doaj   +1 more source

Could the grounds’s grounding the grounded ground the grounded? [PDF]

Analysis, 2017
openaire   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Development of certain aspects of colloid chemistry and physical-chemical mechanics of disperse systems and materials in relation to stability of slopes and grades

Nauka ta progres transportu, 2011
In the article the motive force of the movement the particles in dispersed systems, which include soils, when load is just sole weight of the array was investigated.
A.N. Plugin, L.V. Trikoz, O.S. Gerasimenko, A.A. Plugin, D.A. Plugin, Al. A. Plugin   +5 more
doaj  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Modelling the Importance of Ground and Strong‐Motion Variables on the Damage Status in the 2023 Kahramanmaraş Earthquakes Using Supervised Machine Learning

Geoscience Data Journal
The damage status of 44 locations was investigated, incorporating ground condition parameters such as Vs30, engineering bedrock depth (EBd), and predominant frequency (f0), as well as strong‐motion parameters including PGA, Repi, and Rrup (epicentre and ...
Mustafa Senkaya, Serhat E. Akhanlı, Ali Silahtar, Hasan Karaaslan   +3 more
doaj   +1 more source