Results 71 to 80 of about 651,062 (315)

Study on the Hydrodynamics of a Cownose Ray’s Flapping Pectoral Fin Model near the Ground

open access: yesJournal of Marine Science and Engineering
Cownose rays typically swim close to the ocean floor, and the nearby substrate inevitably influences their swimming performance. In this research, we numerically investigate the propulsive capability of cownose rays swimming near the ground by resolving ...
Yang Luo   +6 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Ground Effects and Stability Analysis of Airfoil Accelerated by Electromagnetic Propulsion

open access: yes气体物理
Aerospace vehicle launched by electromagnetic propulsion is a potential option for future reusable space transportation systems. Complex ground effects and stability issues are induced generally due to the introduction of electromagnetic levitation force.
Xingdong LUO   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Sound Characteristic of Drone Fan and Influence of Ground Effect

open access: diamond, 2022
Seiya Sato   +5 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

A Practical Method for Investigation of Aerodynamic and Longitudinal Static Stability of Wing-in-Ground Effect

open access: yesInternational Journal of Maritime Technology, 2015
The purpose of this paper is to present a fast, economical and practical method for mathematical modeling of aerodynamic characteristics of rectangular wing-in-ground effect (WIG).
Mohammad Saeed Seif, Mohammad Tavakoli
doaj  

Nonlinear Control Strategies for an Autonomous Wing-In-Ground-Effect Vehicle. [PDF]

open access: yesSensors (Basel), 2021
Patria D   +3 more
europepmc   +1 more source

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