Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Nonlinear Control Strategies for an Autonomous Wing-In-Ground-Effect Vehicle. [PDF]
Sensors (Basel), 2021 Patria D +3 more
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Dimensional response analysis of bilinear systems subjected to non-pulselike earthquake ground motions [PDF]
, 2011 The maximum inelastic response of bilinear single-degree-of-freedom systems when subjected to ground motions without distinguishable pulses is revisited with dimensional analysis by identifying time scales and length scales in the time histories of ...
Karavasilis, Theodore L. +8 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Ground water pollution potential of Clark County, Ohio
, 1995 "March, 1995."; Includes bibliographical references (pages 28-34)A ground water pollution potential map of Clark County has been prepared using the DRASTIC mapping process.
Vormelker, Joel D. (Joel David)
core
Large-Eddy Simulations of Wake Vortices in Ground Proximity and Crosswind [PDF]
, 2012 Results from large eddy simulations of the wake vortex behaviour in ground effect with turbulent crosswinds are presented. We have conducted wall-resolved and wall-modelled simulations at different Reynolds numbers to investigate the Reynolds-number ...
Misaka, Takashi +2 more
core
Passive Aeroelastic Control of a Near-Ground Airfoil with a Nonlinear Vibration Absorber
AerospaceThis study explores the use of a passive control technique to mitigate aeroelastic effects on a wing operating near the ground. An aeroelastic model, based on a typical airfoil section, equipped with a nonlinear tuned vibration absorber (NLTVA), is ...
Kailash Dhital, Benjamin Chouvion
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source