Results 81 to 90 of about 2,000,383 (303)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Softening of Magnetic Excitations Leading to Pressure-Induced Quantum Phase Transition in Gapped Spin System KCuCl$_3$

, 2007
KCuCl$_3$ is a three dimensionally coupled spin dimer system, which undergoes a pressure-induced quantum phase transition from a gapped ground state to an antiferromagnetic state at a critical pressure of $P_{\rm c} \simeq 8.2$ kbar. Magnetic excitations
Goto, K., Kakurai, K., Kawakami, J., Oosawa, A., Osakabe, T., TANAKA, HIDEKAZU, Uwatoko, Y., 田中, 秀数   +7 more
core   +1 more source

High pressure magnetic state of MnP probed by means of muon-spin rotation [PDF]

, 2016
We report a detailed $\mu$SR study of the pressure evolution of the magnetic order in the manganese based pnictide MnP, which has been recently found to undergo a superconducting transition under pressure once the magnetic ground state is suppressed ...
Amato, A., Bonfà, P., De Renzi, R., Guguchia, Z., Khasanov, R., Luetkens, H., Morenzoni, E., Zhigadlo, N. D.   +7 more
core   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Observed Ground Pressure Acting on the Lining of a Large-Diameter Shield Tunnel in Sandy Stratum under High Water Pressure

Advances in Civil Engineering, 2020
Accurately evaluating the ground pressure on the tunnel lining greatly helps the structure design of a tunnel. In this study, the earth pressure and water pressure on the tunnel lining of four cross sections of a metro tunnel were measured and analyzed ...
Xue Li, Shunhua Zhou, Honggui Di
doaj   +1 more source

Frequency Extension to THz Range in High Pressure ESR System and Its Application to Shastry-Sutherland Model Compound SrCu$_{2}$(BO$_{3}$)$_{2}$

, 2015
We have made a survey of ceramics for the inner parts of the transmission-type pressure cell to achieve the high pressure and the high transmission in THz range.
Hirao, Yuki, Kawasaki, Kohei, Koike, Yoji, Kudo, Kazutaka, Matsubayashi, Kazuyuki, Matsui, Ryosuke, Ohta, Hitoshi, Okubo, Susumu, Sakurai, Takahiro, Uwatoko, Yoshiya   +9 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Distribution patterns of final negative pressure in vacuum preloading

Yantu gongcheng xuebao, 2019
The distribution patterns of the final negative pressure are investigated in vacuum preloading under impeded bottom boundary in order to demonstrate the degenerated properties of vacuum degree and to determine the final vertical effective stress. Firstly,
HU Ya-yuan 1, QIAN Jing-lin 2, ZHANG Chao-jie 2
doaj   +1 more source