Results 101 to 110 of about 1,362,980 (290)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Soil resistivity and ground resistance for dry and wet soil

Journal of Modern Power Systems and Clean Energy, 2017
In this paper, soil resistivity and ground resistance at two different sites near an electrical substation are measured using a grounding system grid with and without rods.
Md. Abdus Salam, Quazi Mehbubar Rahman, Swee Peng Ang, Fushuan Wen   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Joy and Resistance in Carnival From the Ground Up

Journal of Festive Studies
This piece draws on images and interviews featured in a 2024 outdoor photography exhibit, Carnival from the Ground Up, to explore how the joy of carnival in New Orleans can be read as resistance to the dominant social, political, and economic order ...
Martha Radice, Ryan Hodgson-Rigsbee
doaj   +1 more source

Influence of High-Speed Train Power Consumption and Arc Fault Resistances on a Novel Ground Fault Location Method for 2 × 25 kV Railway Power Supply Systems

Energies, 2018
The 2 × 25 kV power supply system is the most frequently used traction rail system to provide the huge power needed by high-speed trains.
Carlos A. Platero, Jesús Serrano, Máximo López-Toledo, Ricardo Granizo   +3 more
doaj   +1 more source

Evidence for a New Dissipationless Regime in 2D Electronic Transport

, 2002
In an ultra-clean 2D electron system (2DES) subjected to crossed millimeterwave (30--150 GHz) and weak (B < 2 kG) magnetic fields, a series of apparently dissipationless states emerges as the system is detuned from cyclotron resonances.
H. Fröhlich, K. W. West, L. N. Pfeiffer, L. V. Keldysh, M. A. Zudov, R. R. Du, Yu. E. Lozovik, Yu. E. Lozovik   +7 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Resistance coefficients on ground-based winching of timber

Croatian Journal of Forest Engineering, 2005
This paper deals with the research of resistance differences in winching of logs with their thicker or thinner end turned forward.Winching represents traction of wood assortments on the ground from the felling site to the forest vehicle equipped with a ...
Dubravko Horvat, Raffaelle Spinelli, Marijan Šušnjar   +2 more
doaj  

First-Order Phase Transition in a Quantum Hall Ferromagnet

, 1999
The single-particle energy spectrum of a two-dimensional electron gas in a perpendicular magnetic field consists of equally-spaced spin-split Landau levels, whose degeneracy is proportional to the magnetic field strength.
Beltram, Fabio, Jungwirth, Tomas, MacDonald, Allan H., Pellegrini, Vittorio, Piazza, Vincenzo, Wegscheider, Werner   +5 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source