Results 81 to 90 of about 1,362,980 (290)

Production, by co-grinding in a media mill, of porous biodegradable polylactic acid-apatite composite materials for bone tissue engineering [PDF]

, 2009
This paper presents the results of a study of the production of porous biodegradable composite materials by co-grinding, followed by scaffolding. Dry powders of polylactic acid and nanocrystalline carbonated apatite, analogous to bone mineral were co ...
Combes, Christèle, Dechambre, Gérard, Drouet, Christophe, Lamure, Alain, Le Bolay, Nadine, Rey, Christian, Santran, Véronique   +6 more
core   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Collapse of superconductivity in a hybrid tin-graphene Josephson junction array

, 2014
When a Josephson junction array is built with hybrid superconductor/metal/superconductor junctions, a quantum phase transition from a superconducting to a two-dimensional (2D) metallic ground state is predicted to happen upon increasing the junction ...
A Allain, A Kapitulnik, AD Caviglia, Adrien Allain, AK Geim, AM Finkel’shtein, AM Goldman, B Huard, B Spivak, B Spivak, B Spivak, Benjamin Sacépé, BL Al’tshuler, BM Kessler, D Das, D Ephron, DJ Resnick, DW Abraham, E Abrahams, H Aubin, Hadi Arjmandi-Tash, HM Jaeger, HSJ Van der Zant, HSJ Van der Zant, J Biscaras, JM Kosterlitz, K Maki, Konstantin Tikhonov, LG Aslamazov, MA Skvortsov, Mikhail Feigel’man, MPA Fisher, MV Feigelman, MV Feigel’man, MV Feigel’man, MV Feigel’man, N Mason, N Mason, P Phillips, PG De Gennes, RS Thompson, S Eley, SG Den Hartog, V Dobrosavljevic, Vincent Bouchiat, VL Berezinskii, VM Galitski, Y Qin, Y-H Lin, Zheng Han   +49 more
core   +4 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

PRECURSORY AND COSEISMIC CHANGES IN GROUND RESISTIVITY

Journal of Physics of the Earth, 1977
A resistivity variometer of unusually high sensitivity has been in operation at a crustal movement observatory about 60km south of Tokyo since 1968. The variometer records changes in ground resistivity caused by crustal strain in association with tidal loading. When a large earthquake occurs, the variometer often records a step-wise change.
Tsuneji Rikitake, Yoshio Yamazaki
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Microwave microstrip resonator measurements of Y1Ba2Cu3O(7-x) and Bi2Sr2Ca1Cu2O(8-y) thin films [PDF]

Radio frequency (RF) surface resistance measurement experiments on high T(sub c) thin films were performed. The method uses a microstrip resonator comprising a top gold conductor strip, an alumina dielectric layer, and a separate superconductivity ground
Davis, Matthew, Lichtenberg, Christopher L., Wolfe, J. C., Wosik, Jaroslaw   +3 more
core   +1 more source

Enhanced earthing performance by improved design and grounding material properties [PDF]

, 2018
An enhance ground electrode (E.G.E.) is a portable grounding system that acts as an additional grounding system, designed for zero potential reference points. The E.G.E could eliminate the increasing of resistance in grounding conductor as it placed next
Mohd Hasni, Nur Alyaa
core