Results 171 to 180 of about 15,574,905 (336)

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

A numerically based investigation on the symmetry breaking and asymptotic behavior of the ground states to the p-Henon equation

open access: yesElectronic Journal of Differential Equations, 2011
The symmetry breaking phenomenon (SBP) to the Henon equation was first numerically observed in [4] and then theoretically verified on the unit ball $B_n$ in [8].
Xudong Yao, Jianxin Zhou
doaj  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Mathematical Analysis of a Generalized Chiral Quark Soliton Model

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2006
A generalized version of the so-called chiral quark soliton model (CQSM) in nuclear physics is introduced. The Hamiltonian of the generalized CQSM is given by a Dirac type operator with a mass term being an operator-valued function.
Asao Arai
doaj  

All-optical polarization-filtered subwavelength imaging in microwave regime via atom-based polarization holography

open access: yesCommunications Physics
Polarization imaging is essential to reveal rich information of the vectorial nature of microwaves. However, selective imaging of specific polarization components with subwavelength resolution remains challenging. Here, we propose atom-based polarization
Ziyao Lyu   +4 more
doaj   +1 more source

Excited-state downfolding using ground-state formalisms

open access: yesElectronic Structure
Abstract Downfolding coupled cluster (CC) techniques are powerful tools for reducing the dimensionality of many-body quantum problems. This work investigates how ground-state downfolding formalisms can target excited states using non-Aufbau reference determinants, paving the way for applications of quantum computing in excited-state ...
openaire   +2 more sources

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

open access: yesFEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca   +6 more
wiley   +1 more source

Fractional minimization problem on the Nehari manifold

open access: yesElectronic Journal of Differential Equations, 2018
In the framework of fractional Sobolev space, using Nehari manifold and concentration compactness principle, we study a minimization problem in the whole space involving the fractional Laplacian.
Mei Yu, Meina Zhang, Xia Zhang
doaj  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

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