Results 131 to 140 of about 2,722,864 (361)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Ground state solutions for magnetic Schrödinger equations with polynomial growth

open access: yesAdvances in Nonlinear Analysis
In this article, we investigate the following nonlinear magnetic Schrödinger equations: (−i∇+A(x))2u+V(x)u=f1(x,∣v∣2)v,(−i∇+A(x))2v+V(x)v=f2(x,∣u∣2)u,\left\{\begin{array}{l}{\left(-i\nabla +A\left(x))}^{2}u+V\left(x)u={f}_{1}\left(x,{| v| }^{2})v ...
Wu Yan, Chen Peng
doaj   +1 more source

Symmetry and concentration behavior of ground state in axially symmetric domains

open access: yesAbstract and Applied Analysis, 2004
We let Ω(r) be the axially symmetric bounded domains which satisfy some suitable conditions, then the ground-state solutions of the semilinear elliptic equation in Ω(r) are nonaxially symmetric and concentrative on one side.
Tsung-Fang Wu
doaj   +1 more source

Ground state solutions for non-autonomous dynamical systems [PDF]

open access: yesJournal of Mathematical Physics, 2014
We study the existence of periodic solutions for a second order non-autonomous dynamical system. We allow both sublinear and superlinear problems. We obtain ground state solutions.
openaire   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Symmetric ground state solutions of m-coupled nonlinear Schrödinger equations

open access: yesNonlinear Analysis: Theory, Methods & Applications, 2009
We prove the existence of radial and radially decreasing ground states of an m-coupled nonlinear Schrodinger equation with a general nonlinearity.
openaire   +2 more sources

Existence and concentration of ground state solutions for critical Schrödinger equation with steep potential well

open access: yesComputers and Mathematics with Applications, 2019
In this paper, we study the following Schrodinger equation − Δ u + ( 1 + μ a ( x ) ) u = f ( u ) + | u | 2 ∗ − 2 u , in R N , where N ≥ 3 and μ > 0 . We obtain a ground state solution for the above equation.
Li Yin, Xing-Ping Wu
semanticscholar   +1 more source

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