Results 121 to 130 of about 2,722,864 (361)
Existence and concentrate behavior of ground state solutions for critical Choquard equations
Applied Mathematics Letters, 2019 In this paper, we investigate the following Choquard equation ( P ) − Δ u + ( 1 + μ g ( x ) ) u = ( I α ∗ | u | p ) | u | p − 2 u + u 5 in R 3 , where p ∈ ( 2 , 3 ) , α ∈ ( 0 , p − 2 ) , I α is the Riesz potential and the function g ≥ 0 has a potential ...
Gui-Dong Li +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Normalized solutions of NLS equations with mixed nonlocal nonlinearities
Advances in Nonlinear AnalysisWe study the existence and nonexistence of normalized solutions for the nonlinear Schrödinger equation with mixed nonlocal nonlinearities: −Δu=λu+μ(Iα∗∣u∣p)∣u∣p−2u+(Iα∗∣u∣q)∣u∣q−2uinRN,∫RN∣u∣2dx=c,\left\{\begin{array}{ll}-\Delta u=\lambda u+\mu \left({I ...
Zhang Zhenyu, Sun Juntao
doaj +1 more source
Ground State Solutions for the Fractional Klein-Gordon-Maxwell System with Steep Potential Well
, 2022 Qingying Shi
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Ground state solutions for Hamiltonian systems with double exponential growth
Boundary Value ProblemsThis study explores the existence of ground state solutions for a Hamiltonian elliptic system in the whole plane R 2 $\mathbb{R}^{2}$ , involving double exponential growth nonlinearities, which are given by the Trudinger–Moser inequalities in weighted ...
Yony Raúl Santaria Leuyacc
doaj +1 more source
Existence and decay property of ground state solutions for Hamiltonian elliptic system
Communications on Pure and Applied Analysis, 2019 In this paper we study the following nonlinear Hamiltonian elliptic system with gradient term \begin{document}$ \begin{eqnarray*} \left\{ \begin{array}{ll} -\Delta u +\vec{b}(x)\cdot \nabla u +u+V(x)v = f(x, |z|)v, \; \; x\in\mathbb{R}^{N}, \\ -\Delta v -
Jian Zhang, Wen Zhang
semanticscholar +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Asymptotics and symmetries of ground-state and least energy nodal solutions for boundary-value problems with slowly growing superlinearities [PDF]
, 2009 Denis Bonheure +2 more
openalex +1 more source