Results 111 to 120 of about 6,855 (245)

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

Advanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Guan Zheng, Wenhui Yu, Zhongyu Xie   +13 more
wiley   +1 more source

Research on ground deformation induced by large caisson construction at the Zhuchong pumping station in Xinyang, China. [PDF]

Sci Rep
Xu Z, Wang L, Cui Y, Zhang X, Wang S, Tian J.   +5 more
europepmc   +1 more source

Ground Subsidence Following Groundwater Drawdown by Excavating of 500 m Deep Investigation Shafts in Granite Body in Mizunami, Central Japan in 2004-2012

, 2015
Fumiaki Kimata, Yasuhiro Asai, Ryo Honda, Toshiyuki Tanaka, Hiroshi Ishii, Rikio Miyajima   +5 more
openalex   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Supplementary material to "Ground subsidence effects on simulating dynamic high latitude surface inundation under permafrost thaw using CLM5"

, 2019
Altug Ekici, Hanna Lee, David M. Lawrence, Sean Swenson, Catherine Prigent   +4 more
openalex   +1 more source

Gravity‐Tolerant In‐Flight 3D Bioprinting Enabled by Stereolithography for Space Tissue Engineering

Advanced Science, EarlyView.
A flight‐compliant, closed stereolithographic 3D bioprinting system enables robust fabrication of acellular and cell‐laden hydrogel constructs under varying gravitational conditions, including microgravity and hypergravity phases. Printed structures retain dimensional fidelity and high‐resolution features, while cell viability remains high ...
Bianca Lemke, Matthias R. Kollert, Tobias Lam, Tobias Thiele, Nicolas Göbel, Lisa R. Köhn, Gabriela Korus, Lutz Kloke, Georg N. Duda   +8 more
wiley   +1 more source

Investigation of surface subsidence behaviour in multi-slice longwall mining using numerical simulations in Barapukuria coal mine, Bangladesh. [PDF]

Sci Rep
Zhang C, Arif A, Wu J, Habibullah M, Mohammadamini K, Sajib MH, Manohar B.   +6 more
europepmc   +1 more source

An Integrated Study of Highway Pavement Subsidence Using Ground-Based Geophysical and Satellite Methods [PDF]

Michael Frid, Amit Helman, Dror Sharf, Vladimir Frid, Wafa Elias, Dan G. Blumberg   +5 more
openalex   +1 more source

Characteristics of Labile Organic Carbon Fractions Under Different Types of Subsidence Waterlogging Areas in the Coal Mining Area with High Ground Water Table: A Case Study in Xinglongzhuang Coal Mine, China

, 2023
Yanhua Fu, Zhenqi Hu, Qi Zhu, Ying Rong
openalex   +1 more source