Results 71 to 80 of about 182,172 (303)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Deep Learning-Based Screening Test for Cognitive Impairment Using Basic Blood Test Data for Health Examination

Frontiers in Neurology, 2020
Background: In order to develop a new screening test of cognitive impairment, we studied whether cognitive function can be estimated from basic blood test data by applying deep learning models.
Kaoru Sakatani, Kaoru Sakatani, Katsunori Oyama, Lizhen Hu   +3 more
doaj   +1 more source

The SIMCA algorithm for processing Ground Penetrating Radar data and its use in landmine detection [PDF]

, 2012
The main challenge of ground penetrating radar (GPR) based land mine detection is to have an accurate image analysis method that is capable of reducing false alarms.
Cockshott, W.P., Anand Sengodan, Sengodan, A., W. Paul Cockshott   +3 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Ground truth based comparison of saliency maps algorithms

Scientific Reports, 2023
Deep neural networks (DNNs) have achieved outstanding results in domains such as image processing, computer vision, natural language processing and bioinformatics.
Karolina Szczepankiewicz, Adam Popowicz, Kamil Charkiewicz, Katarzyna Nałęcz-Charkiewicz, Michał Szczepankiewicz, Sławomir Lasota, Paweł Zawistowski, Krystian Radlak   +7 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

UAS-Based SAR Repeat-Pass Interferometry With Ground Truth

IEEE Access
Radar systems operating aboard unmanned aerial systems (UASs) or drones are gaining lot of interest in the remote sensing field. UASs have recently been tested as platforms for synthetic aperture radar (SAR) systems. There are many expectations regarding
Alessandra Beni, Lapo Miccinesi, Lorenzo Pagnini, Luca Bigazzi, Andrea Cioncolini, Massimiliano Pieraccini   +5 more
doaj   +1 more source

Ground-Truth Production in the Transcriptorium Project [PDF]

2014 11th IAPR International Workshop on Document Analysis Systems, 2014
Tran Scriptorium is a 3-years project that aims to develop innovative, cost-effective solutions for the indexing, search and full transcription of historical handwritten document images, using Handwritten Text Recognition (HTR) technology. The production of ground-truth (GT) of a dataset of handwritten document images is among the first tasks.
Basilis Gatos, Georgios Louloudis, Tim Causer, Kris Grint, Verónica Romero 0001, Joan-Andreu Sánchez, Alejandro H. Toselli, Enrique Vidal 0001   +7 more
openaire   +2 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source