Results 51 to 60 of about 488,216 (336)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

RSA-PT: A Point Transformer-Based Semantic Segmentation Network for Uninterrupted Operation in a Distribution Network Scene

Sensors
The digitization of uninterrupted operation in the distribution network is of great significance for improving people’s quality of life and promoting economic development. As an important means of achieving digitization, point cloud technology is crucial
Deyu Nie, Linong Wang, Shaocheng Wu, Zhenyang Chen, Yongwen Li, Bin Song   +5 more
doaj   +1 more source

Truths qua Grounds [PDF]

, 2018
A number of philosophers have recently found it congenial to talk in terms of grounding. Grounding discourse features grounding sentences that are answers to questions about what grounds what.
Guigon, Ghislain
core  

Modality [PDF]

, 2020
A survey of the connection between grounding and modality, in particular supervenience. The survey explores three possible connections between grounding and supervenience: (1) supervenience can be analyzed in terms of ...
Kovacs, David Mark
core  

Groundhog Grounding Large Language Models to Holistic Segmentation [PDF]

Computer Vision and Pattern Recognition
Most multimodal large language models (MLLMs) learn language-to-object grounding through causal language modeling where grounded objects are captured by bounding boxes as sequences of location tokens.
Yichi Zhang, Ziqiao Ma, Xiaofeng Gao, Suhaila Shakiah, Qiaozi Gao, Joyce Chai   +5 more
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Differences in M‐components between triggered lightning striking the ground and overhead line

High Voltage
In the summer of 2018–2019, rocket‐triggered lightning experiments were conducted in Guangzhou, China. There were two types of lightning targets: ground and overhead line.
Li Cai, Yiyang Du, Wenchao Fan, Mi Zhou, Jianguo Wang, Jinxin Cao, Yadong Fan   +6 more
doaj   +1 more source

Prediction of Breakdown Voltage of Long Air Gaps Under Switching Impulse Voltage Based on the ISSA-XGBoost Model

Energies
In transmission lines, the discharge characteristics of long air gaps significantly influence the design of external insulation. Existing machine learning models for predicting breakdown voltage are typically limited to single gaps and do not account for
Zisheng Zeng, Bin Song, Shaocheng Wu, Yongwen Li, Deyu Nie, Linong Wang   +5 more
doaj   +1 more source

The Mitigation of Interference on Underground Power Lines Caused by the HVDC Electrode

Energies, 2023
High Voltage Direct Current power links are usually designed to adopt, on a continuous basis or during emergency operations, two grounding plants using the soil or seawater as a link–current return path.
Massimo Brignone, Daniele Mestriner, Paolo Molfino, Mario Nervi, Massimo Marzinotto, Sino Patti   +5 more
doaj   +1 more source