Results 151 to 160 of about 31,817,874 (257)

Group-Based Interventions for Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis of the Role of Trauma Type. [PDF]

Campbell Syst Rev
Whelan É, Griffin SM, Ahern E, Lebedová A, McMahon G, Bradshaw D, Muldoon OT.   +6 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Experiences in group pain management interventions [PDF]

Section A: Presents a narrative literature review using a quality appraisal framework to evaluate the quality of studies exploring the experiences of people with chronic pain attending pain management programmes.
Park, J.
core  

Individual versus group-based interventions: a systematic review and meta-analysis of physical activity, functional, psychosocial and health outcomes. [PDF]

Nat Hum Behav
Kritz M, Riddell H, Olsen D, Harden SM, Burke SM, Ntoumanis N, Thøgersen-Ntoumani C.   +6 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Feasibility and Acceptability of Group-Based Interventions (Offered in English and Spanish) for Caregivers of Children With LAD. [PDF]

Glob Adv Integr Med Health
Park ER, Goshe BM, Miranda I, Finkelstein-Fox L, Nourse P, Williams R, Nicolosi G, Lopez K, de la Cruz R, Barreto E, Millstein RA, Perez GK, Mahaffey B, Abuelo C, Winklosky B, Rippey R, Kuhlthau KA.   +16 more
europepmc   +1 more source

How Group-Based Interventions Can Improve Services for People with Severe Obesity. [PDF]

Curr Obes Rep, 2019
Swancutt D, Tarrant M, Pinkney J.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Group-based interventions to reduce diabetes distress in adults with type 1 diabetes: A rapid realist review of the Reduce and TunedIn interventions. [PDF]

Diabet Med
Sims S, Stenov V, Due-Christensen M, Fisher L, Fabian-Therond C, Peck M, Ahuja S, O'Connor S, Abrams R, Halliday J, Holt RIG, Speight J, Sturt J, Harris R, D‑Stress Study Group.   +14 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source